Proopiomelanocortin-derived peptides, phosphoinositides, cAMP, and aldosterone secretion

Arunabha Ganguly, Shirley Chiou, Leigh A. West, John S. Davis

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Since the intracellular messengers of various proopiomelanocortin-derived peptides remain ambiguous at best, we have investigated the possible involvement of phosphoinositide metabolism in aldosterone secretion evoked by α-MSH, β-LPH, as well as ACTH in rat and calf adrenal glomerulosa cells. We have also examined the cAMP responses in the adrenal glomerulosa cells to α-MSH comparing it with those of ACTH. Our results showed that neither α-MSH, β-LPH, nor ACTH increased inositol triphosphate (IP3) or other inositol phosphates in adrenal glomerulosa cells while increasing aldosterone secretion from the same cells. Angiotensin II, known to cause hydrolysis of the phosphoinositides, increased IP3 in these adrenal cells in a dose-dependent manner. Both ACTH and α-MSH raised the cAMP levels in the calf adrenal glomerulosa cells, although the magnitude of the increase of cAMP in response to ACTH was greater. These findings suggest that IP3 as a mediator of α-MSH-and β-LPH-induced aldosterone secretion is not likely and other mediator(s) may be involved.

Original languageEnglish (US)
Pages (from-to)1143-1148
Number of pages6
JournalJournal of Steroid Biochemistry
Volume33
Issue number6
DOIs
Publication statusPublished - Dec 1989

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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