Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia

S. Chabra, T. Strandjord, Eric S Peeples

Research output: Contribution to journalArticle

Abstract

AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalJournal of Neonatal-Perinatal Medicine
Volume12
Issue number3
DOIs
StatePublished - Jan 1 2019

Fingerprint

Extremely Low Birth Weight Infant
Noninvasive Ventilation
Bronchopulmonary Dysplasia
Intermittent Positive-Pressure Ventilation
Premature Infants
Nose
Continuous Positive Airway Pressure
Mechanical Ventilators
Chi-Square Distribution
Cohort Studies
Logistic Models
Students
Oxygen
Pregnancy

Keywords

  • bronchopulmonary dysplasia
  • chronic lung disease
  • extremely low birth weight infants
  • neutrally-adjusted ventilatory assist
  • Non-invasive ventilation
  • preterm
  • respiratory distress syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia. / Chabra, S.; Strandjord, T.; Peeples, Eric S.

In: Journal of Neonatal-Perinatal Medicine, Vol. 12, No. 3, 01.01.2019, p. 249-253.

Research output: Contribution to journalArticle

@article{c42053c890fb42f7bedea13875ab9acc,
title = "Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia",
abstract = "AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5{\%}, p=0.044) and death or severe BPD (75.0 vs 47.6{\%}, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9{\%} for each additional week on NIPPV (CI 2.1-7.7{\%}, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.",
keywords = "bronchopulmonary dysplasia, chronic lung disease, extremely low birth weight infants, neutrally-adjusted ventilatory assist, Non-invasive ventilation, preterm, respiratory distress syndrome",
author = "S. Chabra and T. Strandjord and Peeples, {Eric S}",
year = "2019",
month = "1",
day = "1",
doi = "10.3233/NPM-18120",
language = "English (US)",
volume = "12",
pages = "249--253",
journal = "Journal of Neonatal-Perinatal Medicine",
issn = "1934-5798",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia

AU - Chabra, S.

AU - Strandjord, T.

AU - Peeples, Eric S

PY - 2019/1/1

Y1 - 2019/1/1

N2 - AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.

AB - AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.

KW - bronchopulmonary dysplasia

KW - chronic lung disease

KW - extremely low birth weight infants

KW - neutrally-adjusted ventilatory assist

KW - Non-invasive ventilation

KW - preterm

KW - respiratory distress syndrome

UR - http://www.scopus.com/inward/record.url?scp=85071664304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071664304&partnerID=8YFLogxK

U2 - 10.3233/NPM-18120

DO - 10.3233/NPM-18120

M3 - Article

VL - 12

SP - 249

EP - 253

JO - Journal of Neonatal-Perinatal Medicine

JF - Journal of Neonatal-Perinatal Medicine

SN - 1934-5798

IS - 3

ER -