Abstract
AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-253 |
| Number of pages | 5 |
| Journal | Journal of Neonatal-Perinatal Medicine |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- bronchopulmonary dysplasia
- chronic lung disease
- extremely low birth weight infants
- neutrally-adjusted ventilatory assist
- Non-invasive ventilation
- preterm
- respiratory distress syndrome
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia. / Chabra, S.; Strandjord, T.; Peeples, Eric S.
In: Journal of Neonatal-Perinatal Medicine, Vol. 12, No. 3, 01.01.2019, p. 249-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolonged non-invasive ventilation in extremely low birth weight preterm infants is associated with bronchopulmonary dysplasia
AU - Chabra, S.
AU - Strandjord, T.
AU - Peeples, Eric S
PY - 2019/1/1
Y1 - 2019/1/1
N2 - AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.
AB - AIM: To evaluate the association between the use of nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) with the development of bronchopulmonary dysplasia (BPD). METHODS: This is a single center retrospective cohort analysis of infants born at ≤1000 grams and ≤28 weeks gestation with respiratory distress treated with nCPAP or NIPPV. Groups were compared using Student's t test or chi-square, and associations estimated by logistic regression. RESULTS: Compared to nCPAP, infants who received NIPPV had a higher incidence of moderate to severe (M-S) BPD (84.2 vs 65.5%, p=0.044) and death or severe BPD (75.0 vs 47.6%, p=0.003). Each day on NIPPV was associated with an increased risk of M-S BPD (OR 1.08, p<0.001) and an increased risk of death or severe BPD (OR 1.03, p=0.006). After adjusting for days on oxygen, ventilator days, and days on all respiratory support, the odds of developing M-S BPD increased by 4.9% for each additional week on NIPPV (CI 2.1-7.7%, p=.0001). CONCLUSION: In this cohort, use of NIPPV was associated with an increased risk for developing BPD when compared to infants receiving nCPAP, and each additional day on NIPPV carried significant increased risk for developing BPD.
KW - bronchopulmonary dysplasia
KW - chronic lung disease
KW - extremely low birth weight infants
KW - neutrally-adjusted ventilatory assist
KW - Non-invasive ventilation
KW - preterm
KW - respiratory distress syndrome
UR - http://www.scopus.com/inward/record.url?scp=85071664304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071664304&partnerID=8YFLogxK
U2 - 10.3233/NPM-18120
DO - 10.3233/NPM-18120
M3 - Article
VL - 12
SP - 249
EP - 253
JO - Journal of Neonatal-Perinatal Medicine
JF - Journal of Neonatal-Perinatal Medicine
SN - 1934-5798
IS - 3
ER -