Proliferative fraction and DNA content are lower in b-cell non-hodgkin's lymphomas with the (t14; 18)

Henlen L. Grierson, Terry N. Wooldridge, Michelle Hess, Anne Ratashak, Leslee Wooldridge, René Fordy Ce-Boyer, Martin Bast, James Olen Armitage, Dennis D. Weisenburger, Warren G. Sanger

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The é (14:18), which juxtaposes the immunoglobulin enhncer from chromosome 14 to the bcl-2 gene on chromosome 18. is a recurrent cytogenetic abnormality in thc majority of follicular lymphomas (FL). This translocation results in overexpression of bcl-2, which increases cellular life span of the mutated cells by decreasing apoptosis. The t(14;18) also occurs in a subgroup of diffuse largc cell lymphomas (DLCL), and current thought is that the majority of these represent transformation of FL. Low grade FL are characterized by low proliferation. and diploidperidiploid DNA content. In this study. we compared proliferative activity (PF) and DNA content (DI) in FL containing the t(14;18) to DLCL with and without the t(14; 18). The mean PF and DI were lower in the NHL containing t(14; 18) irregardless of histologic subtype. We conclude that increased life span due to the presence of t(14; 18) provides the conditions for accumulation of a different set of mutations a. compared to those NHL developing from mutations in more rapidly proliferating precursors. This has implications for prognosis of patients with DLCL depending upon the presence or absence of I(14; 18).

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalLeukemia and Lymphoma
Volume19
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1995

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Keywords

  • Bcl-2
  • DNA content
  • Flow cytometry
  • Non-Hodgkin's
  • Proliferative fraction
  • T(14:18)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Grierson, H. L., Wooldridge, T. N., Hess, M., Ratashak, A., Wooldridge, L., Ce-Boyer, R. F., ... Sanger, W. G. (1995). Proliferative fraction and DNA content are lower in b-cell non-hodgkin's lymphomas with the (t14; 18). Leukemia and Lymphoma, 19(3-4), 253-257. https://doi.org/10.3109/10428199509107895