Proliferative changes in the prostate

Parviz Pour, Terence A. Lawson, Samuel Monroe Cohen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The prostate of the rat has several lobes which have variable responsiveness to estrogens and testosterone. Testosterone is a major stimulant of cell proliferation in the prostate. Chemical carcinogenesis models in the rat prostate have taken advantage of administering the carcinogen during the peak proliferative period following testosterone administration with subsequent testosterone administered to continue the proliferative stimulus. Invasive adenocarcinomas of the prostate have been induced utilizing such methods.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalToxicology and Applied Pharmacology
Volume101
Issue number3
DOIs
StatePublished - Dec 1989

Fingerprint

Testosterone
Prostate
Rats
Chemical Models
Cell proliferation
Carcinogens
Estrogens
Carcinogenesis
Adenocarcinoma
Cell Proliferation

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Proliferative changes in the prostate. / Pour, Parviz; Lawson, Terence A.; Cohen, Samuel Monroe.

In: Toxicology and Applied Pharmacology, Vol. 101, No. 3, 12.1989, p. 499-509.

Research output: Contribution to journalArticle

Pour, Parviz ; Lawson, Terence A. ; Cohen, Samuel Monroe. / Proliferative changes in the prostate. In: Toxicology and Applied Pharmacology. 1989 ; Vol. 101, No. 3. pp. 499-509.
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