Progressive mucocutaneous herpes simplex infection due to acyclovir-resistant virus in an immunocompromised patient: Correlation of viral susceptibilities and plasma levels with response to therapy

Bonnie Bean, Courtney Fletcher, Janet Englund, Sandra Nusinoff Lehrman, M. Nixon Ellis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rapidly progressive disease due to acyclovir-resistant herpes simplex has not been described. We report such a case and detail successful patient management using viral sensitivities and plasma acyclovir levels to guide therapy. Response was correlated with plasma levels above those inhibiting viral growth by 50% (ID50) in vitro.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume7
Issue number3
DOIs
StatePublished - Jul 1987

Fingerprint

Herpes Simplex
Acyclovir
Immunocompromised Host
Viruses
Infection
Therapeutics
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

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