Progression of sugar cataract in the dog.

S. Sato, Y. Takahashi, M. Wyman, Peter F Kador

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Young beagle dogs were fed a 30% galactose diet, with or without the aldose reductase inhibitors sorbinil or M79175. Cataract formation was monitored by indirect ophthalmoscope and hand-held slit-lamp microscopy and documented by retroillumination photography. In these dogs, the first sign of cataract development was an accentuation of the anterior and posterior lens sutures (1 month after feeding), then the appearance of cortical vacuoles (3 months after feeding), and finally, the formation of predominantly equatorial cortical opacities toward the posterior cortices (4-6 months after feeding). After long-term galactose feeding, a progressive, irregular, clear zone formed at the cortical equatorial regions. Light microscopic examination of these lenses shows that the cataracts are osmotic, many of the lens fibers appear to be swollen or ruptured, and vacuoles are seen near the bow region. Moreover, these histologic changes were reduced in a dose-dependent manner in galactose-fed dogs concomitantly treated with the aldose reductase inhibitors sorbinil or M79175. The osmotic nature of these cataracts and the observation that their formation can be reduced in a dose-dependent manner by aldose reductase inhibitors are consistent with the concept that the aldose-reductase catalyzed formation of polar sugar alcohols (polyols) initiates sugar cataract formation in the dog.

Original languageEnglish (US)
Pages (from-to)1925-1931
Number of pages7
JournalInvestigative ophthalmology & visual science
Volume32
Issue number6
StatePublished - Jan 1 1991

Fingerprint

Aldehyde Reductase
Cataract
Dogs
Galactose
Lenses
Vacuoles
Ophthalmoscopes
Sugar Alcohols
Photography
Sutures
Hand
Diet
Light
sorbinil
M 79175

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Progression of sugar cataract in the dog. / Sato, S.; Takahashi, Y.; Wyman, M.; Kador, Peter F.

In: Investigative ophthalmology & visual science, Vol. 32, No. 6, 01.01.1991, p. 1925-1931.

Research output: Contribution to journalArticle

Sato, S, Takahashi, Y, Wyman, M & Kador, PF 1991, 'Progression of sugar cataract in the dog.', Investigative ophthalmology & visual science, vol. 32, no. 6, pp. 1925-1931.
Sato, S. ; Takahashi, Y. ; Wyman, M. ; Kador, Peter F. / Progression of sugar cataract in the dog. In: Investigative ophthalmology & visual science. 1991 ; Vol. 32, No. 6. pp. 1925-1931.
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