Prognostic significance of nuclear pSTAT3 in oral cancer

Muzafar A. MacHa, Ajay Matta, Jatinder Kaur, S. S. Chauhan, Alok Thakar, Nootan K. Shukla, Siddhartha Datta Gupta, Ranju Ralhan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background Aberrant nuclear accumulation of proteins influences tumor development and may predict biologic aggressiveness and disease prognosis. This study determined the prognostic significance of pSTAT3 (phosphorylayed signal transducer and activator of transcription 3) in oral squamous cell carcinomas (OSCCs). Methods and Results Using immunohistochemistry, a significant increase in nuclear accumulation of pSTAT3 was observed in 49 of 90 leukoplakias (54.4%) and 63/94 OSCCs (67%) (ptrend <.001). Increased pSTAT3 was associated with tumor stage (p =.01), nodal metastasis (p =.0018), and tobacco consumption (p =.004). Kaplan-Meier analysis demonstrated that OSCC with increased nuclear pSTAT3 showed significantly reduced disease-free survival (13 months), compared with the patients with no nuclear pSTAT3 expression (64 months, p =.019). Cox regression analysis revealed nuclear pSTAT3 as the most significant predictor of poor prognosis (p =.024, hazard ratio [HR] = 2.7). Conclusions Increased nuclear accumulation of pSTAT3 occurs in early premalignant stages and is a marker for poor prognosis of OSCC.

Original languageEnglish (US)
Pages (from-to)482-489
Number of pages8
JournalHead and Neck
Volume33
Issue number4
DOIs
StatePublished - Apr 1 2011

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STAT3 Transcription Factor
Mouth Neoplasms
Squamous Cell Carcinoma
Leukoplakia
Kaplan-Meier Estimate
Tobacco Use
Nuclear Proteins
Disease-Free Survival
Neoplasms
Immunohistochemistry
Regression Analysis
Neoplasm Metastasis

Keywords

  • OSCC
  • STAT3
  • dysplasia
  • leukoplakia
  • pSTAT3

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

MacHa, M. A., Matta, A., Kaur, J., Chauhan, S. S., Thakar, A., Shukla, N. K., ... Ralhan, R. (2011). Prognostic significance of nuclear pSTAT3 in oral cancer. Head and Neck, 33(4), 482-489. https://doi.org/10.1002/hed.21468

Prognostic significance of nuclear pSTAT3 in oral cancer. / MacHa, Muzafar A.; Matta, Ajay; Kaur, Jatinder; Chauhan, S. S.; Thakar, Alok; Shukla, Nootan K.; Gupta, Siddhartha Datta; Ralhan, Ranju.

In: Head and Neck, Vol. 33, No. 4, 01.04.2011, p. 482-489.

Research output: Contribution to journalArticle

MacHa, MA, Matta, A, Kaur, J, Chauhan, SS, Thakar, A, Shukla, NK, Gupta, SD & Ralhan, R 2011, 'Prognostic significance of nuclear pSTAT3 in oral cancer', Head and Neck, vol. 33, no. 4, pp. 482-489. https://doi.org/10.1002/hed.21468
MacHa MA, Matta A, Kaur J, Chauhan SS, Thakar A, Shukla NK et al. Prognostic significance of nuclear pSTAT3 in oral cancer. Head and Neck. 2011 Apr 1;33(4):482-489. https://doi.org/10.1002/hed.21468
MacHa, Muzafar A. ; Matta, Ajay ; Kaur, Jatinder ; Chauhan, S. S. ; Thakar, Alok ; Shukla, Nootan K. ; Gupta, Siddhartha Datta ; Ralhan, Ranju. / Prognostic significance of nuclear pSTAT3 in oral cancer. In: Head and Neck. 2011 ; Vol. 33, No. 4. pp. 482-489.
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