Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia

J. T. Leimert, C. P. Burns, C. G. Wiltse, J. O. Armitage, W. R. Clarke

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

An analysis of 55 adult patients (age >15 yr) with previously untreated acute lymphoblastic leukemia (ALL) was undertaken to correlate presenting clinical features with outcome of treatment. Patients achieving complete remission (CR) were compared to those without CR for the presence or magnitude of 24 pretreatment characteristics. The effect of each characteristic on remission duration and survival was studied using the proportional hazards method. Younger age predicted longer remission duration and survival but was not related to attainment of CR. The L1 FAB subtype was more frequently associated with CR than was L2. It predicted longer remission duration and survival compared to L2, but when age was considered concurrently, the effect of FAB subtype was lost for remission duration and considerably diminished for survival. The absence of infection favored attainment of CR, and elevated serum creatinine had a negative effect on survival. Statistically less certain associations were marrow cellularity >90% and absence of weight loss favoring CR; female sex and lower neutrophils and hemoglobin favoring longer remission duration; and lower aspartate transaminase favoring longer survival. Total numbers of white cells, blasts or platelets, fever, purpura, organomegaly, lymphadenopathy, and other serum chemistries were not significantly related to outcome. For adults with ALL, these results both confirm and repudiate previously noted prognostic associations and demonstrate that many important prognostic indicators of childhood ALL do not apply to the adult disease.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalBlood
Volume56
Issue number3
StatePublished - Dec 1 1980

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Aspartate Aminotransferases
Platelets
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Creatinine
Hazards
Hemoglobins
Survival
Purpura
Serum
Weight Loss
Neutrophils
Fever
Blood Platelets
Cell Count
Bone Marrow
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Leimert, J. T., Burns, C. P., Wiltse, C. G., Armitage, J. O., & Clarke, W. R. (1980). Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. Blood, 56(3), 510-515.

Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. / Leimert, J. T.; Burns, C. P.; Wiltse, C. G.; Armitage, J. O.; Clarke, W. R.

In: Blood, Vol. 56, No. 3, 01.12.1980, p. 510-515.

Research output: Contribution to journalArticle

Leimert, JT, Burns, CP, Wiltse, CG, Armitage, JO & Clarke, WR 1980, 'Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia', Blood, vol. 56, no. 3, pp. 510-515.
Leimert JT, Burns CP, Wiltse CG, Armitage JO, Clarke WR. Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. Blood. 1980 Dec 1;56(3):510-515.
Leimert, J. T. ; Burns, C. P. ; Wiltse, C. G. ; Armitage, J. O. ; Clarke, W. R. / Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. In: Blood. 1980 ; Vol. 56, No. 3. pp. 510-515.
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