[Prognostic factors of nasal NK/T-cell lymphoma].

Qin Ma, Hui lai Zhang, Xia Liu, Shi yong Zhou, Zheng zi Qian, Qiong li Zhai, Kai Fu, Hua qing Wang

Research output: Contribution to journalArticle

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Abstract

To investigate the prognostic predictors of nasal NK/T cell lymphoma. Records of 80 patients with nasal NK/T cell lymphoma were analyzed retrospectively. The correlation between clinical and haematological factors and prognosis was analyzed with univariate and multivariate analysis. After treatment, 33 of 80 patients achieved complete response, the 5-year overall survival and progression free survival were 52.5% and 32.5%, respectively. In univariate analysis, Eastern Cooperative Oncology Group performance status, Ann Arbor stage, local tumor invasion out of the nasal cavity, international prognostic index, complete response rate to the primary treatment, treatment model, lactate dehydrogenase (LDH),β2-microglobulin level, globulin and white blood cell were found to be the prognostic factors. Multivariate analysis indicated that unfavorable prognostic factors included complete response rate to the primary treatment (χ(2) = 17.109, P < 0.01), LDH(χ(2) = 15.695, P < 0.01), and local tumor invasion out of the nasal cavity (χ(2) = 13.503, P < 0.01). Complete response rate to the primary treatment, elevated plasma LDH and tumor invasion out of the nasal cavity may be independent prognostic factors for NK/T cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1011-1016
Number of pages6
JournalUnknown Journal
Volume48
Issue number12
StatePublished - Dec 2013

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T-cells
T-Cell Lymphoma
Nose
Natural Killer Cells
Tumors
Nasal Cavity
Oncology
Globulins
L-Lactate Dehydrogenase
Multivariate Analysis
Blood
Therapeutics
Neoplasms
Cells
Plasmas
Disease-Free Survival
Leukocytes
Survival
lactate dehydrogenase 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ma, Q., Zhang, H. L., Liu, X., Zhou, S. Y., Qian, Z. Z., Zhai, Q. L., ... Wang, H. Q. (2013). [Prognostic factors of nasal NK/T-cell lymphoma]. Unknown Journal, 48(12), 1011-1016.

[Prognostic factors of nasal NK/T-cell lymphoma]. / Ma, Qin; Zhang, Hui lai; Liu, Xia; Zhou, Shi yong; Qian, Zheng zi; Zhai, Qiong li; Fu, Kai; Wang, Hua qing.

In: Unknown Journal, Vol. 48, No. 12, 12.2013, p. 1011-1016.

Research output: Contribution to journalArticle

Ma, Q, Zhang, HL, Liu, X, Zhou, SY, Qian, ZZ, Zhai, QL, Fu, K & Wang, HQ 2013, '[Prognostic factors of nasal NK/T-cell lymphoma].', Unknown Journal, vol. 48, no. 12, pp. 1011-1016.
Ma Q, Zhang HL, Liu X, Zhou SY, Qian ZZ, Zhai QL et al. [Prognostic factors of nasal NK/T-cell lymphoma]. Unknown Journal. 2013 Dec;48(12):1011-1016.
Ma, Qin ; Zhang, Hui lai ; Liu, Xia ; Zhou, Shi yong ; Qian, Zheng zi ; Zhai, Qiong li ; Fu, Kai ; Wang, Hua qing. / [Prognostic factors of nasal NK/T-cell lymphoma]. In: Unknown Journal. 2013 ; Vol. 48, No. 12. pp. 1011-1016.
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abstract = "To investigate the prognostic predictors of nasal NK/T cell lymphoma. Records of 80 patients with nasal NK/T cell lymphoma were analyzed retrospectively. The correlation between clinical and haematological factors and prognosis was analyzed with univariate and multivariate analysis. After treatment, 33 of 80 patients achieved complete response, the 5-year overall survival and progression free survival were 52.5{\%} and 32.5{\%}, respectively. In univariate analysis, Eastern Cooperative Oncology Group performance status, Ann Arbor stage, local tumor invasion out of the nasal cavity, international prognostic index, complete response rate to the primary treatment, treatment model, lactate dehydrogenase (LDH),β2-microglobulin level, globulin and white blood cell were found to be the prognostic factors. Multivariate analysis indicated that unfavorable prognostic factors included complete response rate to the primary treatment (χ(2) = 17.109, P < 0.01), LDH(χ(2) = 15.695, P < 0.01), and local tumor invasion out of the nasal cavity (χ(2) = 13.503, P < 0.01). Complete response rate to the primary treatment, elevated plasma LDH and tumor invasion out of the nasal cavity may be independent prognostic factors for NK/T cell lymphoma.",
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AB - To investigate the prognostic predictors of nasal NK/T cell lymphoma. Records of 80 patients with nasal NK/T cell lymphoma were analyzed retrospectively. The correlation between clinical and haematological factors and prognosis was analyzed with univariate and multivariate analysis. After treatment, 33 of 80 patients achieved complete response, the 5-year overall survival and progression free survival were 52.5% and 32.5%, respectively. In univariate analysis, Eastern Cooperative Oncology Group performance status, Ann Arbor stage, local tumor invasion out of the nasal cavity, international prognostic index, complete response rate to the primary treatment, treatment model, lactate dehydrogenase (LDH),β2-microglobulin level, globulin and white blood cell were found to be the prognostic factors. Multivariate analysis indicated that unfavorable prognostic factors included complete response rate to the primary treatment (χ(2) = 17.109, P < 0.01), LDH(χ(2) = 15.695, P < 0.01), and local tumor invasion out of the nasal cavity (χ(2) = 13.503, P < 0.01). Complete response rate to the primary treatment, elevated plasma LDH and tumor invasion out of the nasal cavity may be independent prognostic factors for NK/T cell lymphoma.

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