Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma

Marin Nola, Steven Z. Pavletic, Dennis D. Weisenburger, Lynette M Smith, Martin A. Bast, Julie Marie Vose, James Olen Armitage

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The term "B-cell small lymphocytic lymphoma" (B-SLL) is generally reserved for patients with lymph node masses that show the histology and immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) but who are not leukemic. The aim of our study was to define clinical factors that predict for survival in B-SLL. Thirty-nine patients with B-SLL and with less than 5,000 mature-appearing lymphocytes/gL in the peripheral blood were studied. The median follow-up of survivors was 6.6 years (range, 1.6-12.3 years). The estimated 5-year overall survival (OS) and failure-free survival (FFS) were 66% and 23%, respectively. In the univariate analysis, significant adverse predictors for OS were age ≥60 years, B symptoms, elevated serum LDH, low hemoglobin (<11 g/dL), and high International Prognostic Index (IPI) score (3-5). In multivariate analysis, the IPI score was the only significant predictor of OS. Anemia and B symptoms were additionally predictive of poor OS in patients with low IPI scores.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalAmerican Journal of Hematology
Volume77
Issue number1
DOIs
StatePublished - Sep 1 2004

Fingerprint

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Survival
Survivors
Anemia
Histology
Hemoglobins
Multivariate Analysis
Lymph Nodes
Lymphocytes
Serum

Keywords

  • B-CLL
  • B-SLL
  • B-cell chronic lymphocytic leukemia
  • B-cell small lymphocytic lymphoma
  • Prognosis
  • Small lymphocytic lymphoma prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma. / Nola, Marin; Pavletic, Steven Z.; Weisenburger, Dennis D.; Smith, Lynette M; Bast, Martin A.; Vose, Julie Marie; Armitage, James Olen.

In: American Journal of Hematology, Vol. 77, No. 1, 01.09.2004, p. 31-35.

Research output: Contribution to journalArticle

Nola, Marin ; Pavletic, Steven Z. ; Weisenburger, Dennis D. ; Smith, Lynette M ; Bast, Martin A. ; Vose, Julie Marie ; Armitage, James Olen. / Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma. In: American Journal of Hematology. 2004 ; Vol. 77, No. 1. pp. 31-35.
@article{61ba5c59a0214d4b86aa625b00d66f27,
title = "Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma",
abstract = "The term {"}B-cell small lymphocytic lymphoma{"} (B-SLL) is generally reserved for patients with lymph node masses that show the histology and immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) but who are not leukemic. The aim of our study was to define clinical factors that predict for survival in B-SLL. Thirty-nine patients with B-SLL and with less than 5,000 mature-appearing lymphocytes/gL in the peripheral blood were studied. The median follow-up of survivors was 6.6 years (range, 1.6-12.3 years). The estimated 5-year overall survival (OS) and failure-free survival (FFS) were 66{\%} and 23{\%}, respectively. In the univariate analysis, significant adverse predictors for OS were age ≥60 years, B symptoms, elevated serum LDH, low hemoglobin (<11 g/dL), and high International Prognostic Index (IPI) score (3-5). In multivariate analysis, the IPI score was the only significant predictor of OS. Anemia and B symptoms were additionally predictive of poor OS in patients with low IPI scores.",
keywords = "B-CLL, B-SLL, B-cell chronic lymphocytic leukemia, B-cell small lymphocytic lymphoma, Prognosis, Small lymphocytic lymphoma prognosis",
author = "Marin Nola and Pavletic, {Steven Z.} and Weisenburger, {Dennis D.} and Smith, {Lynette M} and Bast, {Martin A.} and Vose, {Julie Marie} and Armitage, {James Olen}",
year = "2004",
month = "9",
day = "1",
doi = "10.1002/ajh.20137",
language = "English (US)",
volume = "77",
pages = "31--35",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Prognostic factors influencing survival in patients with B-cell small lymphocytic lymphoma

AU - Nola, Marin

AU - Pavletic, Steven Z.

AU - Weisenburger, Dennis D.

AU - Smith, Lynette M

AU - Bast, Martin A.

AU - Vose, Julie Marie

AU - Armitage, James Olen

PY - 2004/9/1

Y1 - 2004/9/1

N2 - The term "B-cell small lymphocytic lymphoma" (B-SLL) is generally reserved for patients with lymph node masses that show the histology and immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) but who are not leukemic. The aim of our study was to define clinical factors that predict for survival in B-SLL. Thirty-nine patients with B-SLL and with less than 5,000 mature-appearing lymphocytes/gL in the peripheral blood were studied. The median follow-up of survivors was 6.6 years (range, 1.6-12.3 years). The estimated 5-year overall survival (OS) and failure-free survival (FFS) were 66% and 23%, respectively. In the univariate analysis, significant adverse predictors for OS were age ≥60 years, B symptoms, elevated serum LDH, low hemoglobin (<11 g/dL), and high International Prognostic Index (IPI) score (3-5). In multivariate analysis, the IPI score was the only significant predictor of OS. Anemia and B symptoms were additionally predictive of poor OS in patients with low IPI scores.

AB - The term "B-cell small lymphocytic lymphoma" (B-SLL) is generally reserved for patients with lymph node masses that show the histology and immunophenotype of B-cell chronic lymphocytic leukemia (B-CLL) but who are not leukemic. The aim of our study was to define clinical factors that predict for survival in B-SLL. Thirty-nine patients with B-SLL and with less than 5,000 mature-appearing lymphocytes/gL in the peripheral blood were studied. The median follow-up of survivors was 6.6 years (range, 1.6-12.3 years). The estimated 5-year overall survival (OS) and failure-free survival (FFS) were 66% and 23%, respectively. In the univariate analysis, significant adverse predictors for OS were age ≥60 years, B symptoms, elevated serum LDH, low hemoglobin (<11 g/dL), and high International Prognostic Index (IPI) score (3-5). In multivariate analysis, the IPI score was the only significant predictor of OS. Anemia and B symptoms were additionally predictive of poor OS in patients with low IPI scores.

KW - B-CLL

KW - B-SLL

KW - B-cell chronic lymphocytic leukemia

KW - B-cell small lymphocytic lymphoma

KW - Prognosis

KW - Small lymphocytic lymphoma prognosis

UR - http://www.scopus.com/inward/record.url?scp=4243180375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4243180375&partnerID=8YFLogxK

U2 - 10.1002/ajh.20137

DO - 10.1002/ajh.20137

M3 - Article

C2 - 15307103

AN - SCOPUS:4243180375

VL - 77

SP - 31

EP - 35

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 1

ER -