Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma

A multicenter study

Jorge J. Castillo, Brady E. Beltran, Michele Bibas, Mark Bower, Jaime A. Collins, Kate Cwynarski, Jose L. Diez-Martin, Francisco Hernandez-Ilizaliturri, Steven M. Horwitz, Silvia Montoto, Liron Pantanowitz, Josep Maria Ribera, Julie Marie Vose

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

HIV infection has been associated with an increased risk of developing several types of malignancies, including aggressive peripheral T-cell lymphomas (PTCL). However, this is a rare occurrence with no more than a hundred cases reported in the literature. The purpose of this multicenter study is to describe the characteristics and to identify prognostic factors in patients with HIV-associated PTCL. Data from HIV-positive patients with a pathological diagnosis of non-primary cutaneous, non-leukemic PTCL were gathered retrospectively and are reported using descriptive statistics. Univariate and multivariate survival analyses were also performed. Fifty one patients were included in our analysis. Median age was 38 years with a 5:1 male-to-female ratio. Patients presented with a median CD4+ count of 173 cells mm-3, and a median HIV viral load of 334,787 copies ml-1. The median time from HIV diagnosis to PTCL diagnosis was 4.5 years. About 75% of patients presented with advanced clinical stage and 66% with B symptoms. The most common subtypes were PTCLU (61%) and anaplastic large cell lymphoma (ALCL, 22%). None of the ALCL patients tested expressed ALK. The median overall survival (OS) for the group was 12 months. In the multivariate survival analysis, the use of HAART and patients' performance status were independently associated with OS. HIV-associated PTCL presents predominantly in young men with low CD4+ counts and high HIV viral loads. Both HIV-related and lymphoma-related factors were associated with OS.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalAmerican Journal of Hematology
Volume86
Issue number3
DOIs
StatePublished - Mar 1 2011

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Peripheral T-Cell Lymphoma
Multicenter Studies
HIV
CD4 Lymphocyte Count
Survival Analysis
Viral Load
Survival
Multivariate Analysis
AIDS-Related Lymphoma
Anaplastic Large-Cell Lymphoma
Highly Active Antiretroviral Therapy
HIV Infections
Skin

ASJC Scopus subject areas

  • Hematology

Cite this

Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma : A multicenter study. / Castillo, Jorge J.; Beltran, Brady E.; Bibas, Michele; Bower, Mark; Collins, Jaime A.; Cwynarski, Kate; Diez-Martin, Jose L.; Hernandez-Ilizaliturri, Francisco; Horwitz, Steven M.; Montoto, Silvia; Pantanowitz, Liron; Ribera, Josep Maria; Vose, Julie Marie.

In: American Journal of Hematology, Vol. 86, No. 3, 01.03.2011, p. 256-261.

Research output: Contribution to journalArticle

Castillo, JJ, Beltran, BE, Bibas, M, Bower, M, Collins, JA, Cwynarski, K, Diez-Martin, JL, Hernandez-Ilizaliturri, F, Horwitz, SM, Montoto, S, Pantanowitz, L, Ribera, JM & Vose, JM 2011, 'Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma: A multicenter study', American Journal of Hematology, vol. 86, no. 3, pp. 256-261. https://doi.org/10.1002/ajh.21947
Castillo, Jorge J. ; Beltran, Brady E. ; Bibas, Michele ; Bower, Mark ; Collins, Jaime A. ; Cwynarski, Kate ; Diez-Martin, Jose L. ; Hernandez-Ilizaliturri, Francisco ; Horwitz, Steven M. ; Montoto, Silvia ; Pantanowitz, Liron ; Ribera, Josep Maria ; Vose, Julie Marie. / Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma : A multicenter study. In: American Journal of Hematology. 2011 ; Vol. 86, No. 3. pp. 256-261.
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