PROFESS

a PROtein function, evolution, structure and sequence database.

Thomas Triplet, Matthew D. Shortridge, Mark A Griep, Jaime L. Stark, Robert Powers, Peter Revesz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The proliferation of biological databases and the easy access enabled by the Internet is having a beneficial impact on biological sciences and transforming the way research is conducted. There are approximately 1100 molecular biology databases dispersed throughout the Internet. To assist in the functional, structural and evolutionary analysis of the abundant number of novel proteins continually identified from whole-genome sequencing, we introduce the PROFESS (PROtein Function, Evolution, Structure and Sequence) database. Our database is designed to be versatile and expandable and will not confine analysis to a pre-existing set of data relationships. A fundamental component of this approach is the development of an intuitive query system that incorporates a variety of similarity functions capable of generating data relationships not conceived during the creation of the database. The utility of PROFESS is demonstrated by the analysis of the structural drift of homologous proteins and the identification of potential pancreatic cancer therapeutic targets based on the observation of protein-protein interaction networks. Database URL: http://cse.unl.edu/~profess/

Original languageEnglish (US)
JournalDatabase : the journal of biological databases and curation
Volume2010
DOIs
StatePublished - Jan 1 2010

Fingerprint

amino acid sequences
Databases
Proteins
proteins
Internet
Chemical Databases
Protein Interaction Maps
Biological Science Disciplines
Protein Sequence Analysis
pancreatic neoplasms
Molecular biology
Pancreatic Neoplasms
protein-protein interactions
Molecular Biology
molecular biology
Observation
Genome
Genes
Biological Sciences
therapeutics

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

PROFESS : a PROtein function, evolution, structure and sequence database. / Triplet, Thomas; Shortridge, Matthew D.; Griep, Mark A; Stark, Jaime L.; Powers, Robert; Revesz, Peter.

In: Database : the journal of biological databases and curation, Vol. 2010, 01.01.2010.

Research output: Contribution to journalArticle

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