Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus

A. Adachi, S. Koenig, Howard Eliot Gendelman, D. Daugherty, S. Gattoni-Celli, A. S. Fauci, M. A. Martin

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(A)+ CD4 RNA, whereas uninfectible colon carcinoma and rhabdomyosarcoma cell lines synthesized no detectable T4 RNA. A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalJournal of virology
Volume61
Issue number1
StatePublished - Feb 25 1987

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Human immunodeficiency virus
cell lines
HIV
Cell Line
Infection
infection
carcinoma
colon
Colon
Carcinoma
RNA
Rhabdomyosarcoma
colorectal neoplasms
mucosa
Colorectal Neoplasms
Mucous Membrane
Messenger RNA

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Adachi, A., Koenig, S., Gendelman, H. E., Daugherty, D., Gattoni-Celli, S., Fauci, A. S., & Martin, M. A. (1987). Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. Journal of virology, 61(1), 209-213.

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. / Adachi, A.; Koenig, S.; Gendelman, Howard Eliot; Daugherty, D.; Gattoni-Celli, S.; Fauci, A. S.; Martin, M. A.

In: Journal of virology, Vol. 61, No. 1, 25.02.1987, p. 209-213.

Research output: Contribution to journalArticle

Adachi, A, Koenig, S, Gendelman, HE, Daugherty, D, Gattoni-Celli, S, Fauci, AS & Martin, MA 1987, 'Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus', Journal of virology, vol. 61, no. 1, pp. 209-213.
Adachi A, Koenig S, Gendelman HE, Daugherty D, Gattoni-Celli S, Fauci AS et al. Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. Journal of virology. 1987 Feb 25;61(1):209-213.
Adachi, A. ; Koenig, S. ; Gendelman, Howard Eliot ; Daugherty, D. ; Gattoni-Celli, S. ; Fauci, A. S. ; Martin, M. A. / Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. In: Journal of virology. 1987 ; Vol. 61, No. 1. pp. 209-213.
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