Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5

Luwen Zhang, P. Maruthi Mohan, R. Padmanabhan

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

Original languageEnglish (US)
Pages (from-to)7549-7554
Number of pages6
JournalJournal of virology
Volume66
Issue number12
StatePublished - Dec 1 1992

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Polyproteins
Dengue virus
Dengue Virus
Organelles
organelles
Cytoplasm
Peptide Hydrolases
proteinases
cytoplasm
polyproteins

ASJC Scopus subject areas

  • Immunology

Cite this

Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. / Zhang, Luwen; Mohan, P. Maruthi; Padmanabhan, R.

In: Journal of virology, Vol. 66, No. 12, 01.12.1992, p. 7549-7554.

Research output: Contribution to journalArticle

Zhang, Luwen ; Mohan, P. Maruthi ; Padmanabhan, R. / Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. In: Journal of virology. 1992 ; Vol. 66, No. 12. pp. 7549-7554.
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