Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II)

Daniel M. Hays, R. Beverly Raney, Walter Lawrence, Melvin Tefft, Edward H. Soule, William M. Crist, Mary Foulkes, Harold M. Maurer, Rhabdomyosarcoma Study Committee Intergroup

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Twenty-nine children (24, male: 5, female) with non-disseminated rhabomyosarcomas of the bladder or prostate were treated (1978-1980) by a primary chemotherapy regimen consisting of vincristine, actinomycin D, and cyclosphamide ("pulse" VAC), with or without local radiotherapy. During the initial 20 wk of chemotherapy, nine children achieved a Clinical Complete Response (CCR). Three of these are without evidence of disease (NED) and have functional bladders, two following partial cystectomy. Four who achieved a CCR subsequently relapsed or remained biopsy positive, but are at present NED following radiotherapy and anterior exenteration. Two patients who achieved CCR status relapsed and have died of disease. Twelve patients had a Clinical Partial Response (CPR) in <20 wk and two others in <40 wk. Seven of these are NED with intact bladders following chemotherapy-radiotherapy; and an additional patient is NED following partial cystectomy. Four patients in the CPR group have been treated by exenteration following failure to achieve complete response, and are NED. One patient had died, and one has progressive disease. Six patients had an inadequate response to chemotherapy (NR). Anterior exenteration was carried out in three, and two of these have survived. The overall results in these 29 patients are: (A) alive and disease-free with functional bladders, 11; (B) alive and disease-free following anterior exenteration, 10; and (C) dead or death from tumor anticipated, 8. The function of retained bladders (11) has been satisfactory.

Original languageEnglish (US)
Pages (from-to)812-820
Number of pages9
JournalJournal of pediatric surgery
Volume17
Issue number6
DOIs
StatePublished - Dec 1982

Fingerprint

Rhabdomyosarcoma
Urinary Bladder Neoplasms
Prostate
Drug Therapy
Urinary Bladder
Radiotherapy
Cystectomy
Therapeutics
Dactinomycin
Vincristine
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Hays, D. M., Beverly Raney, R., Lawrence, W., Tefft, M., Soule, E. H., Crist, W. M., ... Intergroup, R. S. C. (1982). Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II). Journal of pediatric surgery, 17(6), 812-820. https://doi.org/10.1016/S0022-3468(82)80449-1

Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II). / Hays, Daniel M.; Beverly Raney, R.; Lawrence, Walter; Tefft, Melvin; Soule, Edward H.; Crist, William M.; Foulkes, Mary; Maurer, Harold M.; Intergroup, Rhabdomyosarcoma Study Committee.

In: Journal of pediatric surgery, Vol. 17, No. 6, 12.1982, p. 812-820.

Research output: Contribution to journalArticle

Hays, DM, Beverly Raney, R, Lawrence, W, Tefft, M, Soule, EH, Crist, WM, Foulkes, M, Maurer, HM & Intergroup, RSC 1982, 'Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II)', Journal of pediatric surgery, vol. 17, no. 6, pp. 812-820. https://doi.org/10.1016/S0022-3468(82)80449-1
Hays, Daniel M. ; Beverly Raney, R. ; Lawrence, Walter ; Tefft, Melvin ; Soule, Edward H. ; Crist, William M. ; Foulkes, Mary ; Maurer, Harold M. ; Intergroup, Rhabdomyosarcoma Study Committee. / Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II). In: Journal of pediatric surgery. 1982 ; Vol. 17, No. 6. pp. 812-820.
@article{7edac9a30c10472087cc96143b412076,
title = "Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II)",
abstract = "Twenty-nine children (24, male: 5, female) with non-disseminated rhabomyosarcomas of the bladder or prostate were treated (1978-1980) by a primary chemotherapy regimen consisting of vincristine, actinomycin D, and cyclosphamide ({"}pulse{"} VAC), with or without local radiotherapy. During the initial 20 wk of chemotherapy, nine children achieved a Clinical Complete Response (CCR). Three of these are without evidence of disease (NED) and have functional bladders, two following partial cystectomy. Four who achieved a CCR subsequently relapsed or remained biopsy positive, but are at present NED following radiotherapy and anterior exenteration. Two patients who achieved CCR status relapsed and have died of disease. Twelve patients had a Clinical Partial Response (CPR) in <20 wk and two others in <40 wk. Seven of these are NED with intact bladders following chemotherapy-radiotherapy; and an additional patient is NED following partial cystectomy. Four patients in the CPR group have been treated by exenteration following failure to achieve complete response, and are NED. One patient had died, and one has progressive disease. Six patients had an inadequate response to chemotherapy (NR). Anterior exenteration was carried out in three, and two of these have survived. The overall results in these 29 patients are: (A) alive and disease-free with functional bladders, 11; (B) alive and disease-free following anterior exenteration, 10; and (C) dead or death from tumor anticipated, 8. The function of retained bladders (11) has been satisfactory.",
author = "Hays, {Daniel M.} and {Beverly Raney}, R. and Walter Lawrence and Melvin Tefft and Soule, {Edward H.} and Crist, {William M.} and Mary Foulkes and Maurer, {Harold M.} and Intergroup, {Rhabdomyosarcoma Study Committee}",
year = "1982",
month = "12",
doi = "10.1016/S0022-3468(82)80449-1",
language = "English (US)",
volume = "17",
pages = "812--820",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Primary chemotherapy in the treatment of children with bladder-prostate tumors in the intergroup rhabdomyosarcoma study (IRS-II)

AU - Hays, Daniel M.

AU - Beverly Raney, R.

AU - Lawrence, Walter

AU - Tefft, Melvin

AU - Soule, Edward H.

AU - Crist, William M.

AU - Foulkes, Mary

AU - Maurer, Harold M.

AU - Intergroup, Rhabdomyosarcoma Study Committee

PY - 1982/12

Y1 - 1982/12

N2 - Twenty-nine children (24, male: 5, female) with non-disseminated rhabomyosarcomas of the bladder or prostate were treated (1978-1980) by a primary chemotherapy regimen consisting of vincristine, actinomycin D, and cyclosphamide ("pulse" VAC), with or without local radiotherapy. During the initial 20 wk of chemotherapy, nine children achieved a Clinical Complete Response (CCR). Three of these are without evidence of disease (NED) and have functional bladders, two following partial cystectomy. Four who achieved a CCR subsequently relapsed or remained biopsy positive, but are at present NED following radiotherapy and anterior exenteration. Two patients who achieved CCR status relapsed and have died of disease. Twelve patients had a Clinical Partial Response (CPR) in <20 wk and two others in <40 wk. Seven of these are NED with intact bladders following chemotherapy-radiotherapy; and an additional patient is NED following partial cystectomy. Four patients in the CPR group have been treated by exenteration following failure to achieve complete response, and are NED. One patient had died, and one has progressive disease. Six patients had an inadequate response to chemotherapy (NR). Anterior exenteration was carried out in three, and two of these have survived. The overall results in these 29 patients are: (A) alive and disease-free with functional bladders, 11; (B) alive and disease-free following anterior exenteration, 10; and (C) dead or death from tumor anticipated, 8. The function of retained bladders (11) has been satisfactory.

AB - Twenty-nine children (24, male: 5, female) with non-disseminated rhabomyosarcomas of the bladder or prostate were treated (1978-1980) by a primary chemotherapy regimen consisting of vincristine, actinomycin D, and cyclosphamide ("pulse" VAC), with or without local radiotherapy. During the initial 20 wk of chemotherapy, nine children achieved a Clinical Complete Response (CCR). Three of these are without evidence of disease (NED) and have functional bladders, two following partial cystectomy. Four who achieved a CCR subsequently relapsed or remained biopsy positive, but are at present NED following radiotherapy and anterior exenteration. Two patients who achieved CCR status relapsed and have died of disease. Twelve patients had a Clinical Partial Response (CPR) in <20 wk and two others in <40 wk. Seven of these are NED with intact bladders following chemotherapy-radiotherapy; and an additional patient is NED following partial cystectomy. Four patients in the CPR group have been treated by exenteration following failure to achieve complete response, and are NED. One patient had died, and one has progressive disease. Six patients had an inadequate response to chemotherapy (NR). Anterior exenteration was carried out in three, and two of these have survived. The overall results in these 29 patients are: (A) alive and disease-free with functional bladders, 11; (B) alive and disease-free following anterior exenteration, 10; and (C) dead or death from tumor anticipated, 8. The function of retained bladders (11) has been satisfactory.

UR - http://www.scopus.com/inward/record.url?scp=0020354977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020354977&partnerID=8YFLogxK

U2 - 10.1016/S0022-3468(82)80449-1

DO - 10.1016/S0022-3468(82)80449-1

M3 - Article

C2 - 6761418

AN - SCOPUS:0020354977

VL - 17

SP - 812

EP - 820

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 6

ER -