Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential

Matthew L. White, Drew W. Moore, Yan Zhang, Keiper D. Mark, Timothy C. Greiner, Philip J. Bierman

Research output: Contribution to journalReview article

Abstract

Objective: Central nervous system post-transplant lymphoproliferative disorder (CNS-PTLD) is a rare disease that presents with non-specific signs and symptoms. The purpose of this article is to present the imaging appearances of CNS-PTLD by magnetic resonance imaging. We highlight the differential diagnostic considerations including primary central nervous system lymphoma, glioblastoma, cerebral abscess, and metastatic disease. This is an important topic to review since in daily practice the diagnosis of CNS-PTLD is often not initially considered when present due to its rarity and the lack of radiologists’ familiarity with the disease. Conclusion: Knowing the unique imaging features of CNS-PTLD narrows the differential diagnosis, facilitates the diagnostic work-up, and optimizes making the diagnosis. Advanced MRI data for CNS PTLD is limited but is promising for helping with narrowing the differential diagnosis.

Original languageEnglish (US)
Article number46
JournalInsights into Imaging
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Lymphoproliferative Disorders
Central Nervous System
Transplants
Differential Diagnosis
Brain Abscess
Glioblastoma
Rare Diseases
Signs and Symptoms
Lymphoma
Magnetic Resonance Imaging

Keywords

  • CT
  • Central nervous system
  • Clinical features
  • MRI
  • Post-transplant lymphoproliferative disorders

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Primary central nervous system post-transplant lymphoproliferative disorders : the spectrum of imaging appearances and differential. / White, Matthew L.; Moore, Drew W.; Zhang, Yan; Mark, Keiper D.; Greiner, Timothy C.; Bierman, Philip J.

In: Insights into Imaging, Vol. 10, No. 1, 46, 01.12.2019.

Research output: Contribution to journalReview article

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AU - White, Matthew L.

AU - Moore, Drew W.

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AU - Greiner, Timothy C.

AU - Bierman, Philip J.

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N2 - Objective: Central nervous system post-transplant lymphoproliferative disorder (CNS-PTLD) is a rare disease that presents with non-specific signs and symptoms. The purpose of this article is to present the imaging appearances of CNS-PTLD by magnetic resonance imaging. We highlight the differential diagnostic considerations including primary central nervous system lymphoma, glioblastoma, cerebral abscess, and metastatic disease. This is an important topic to review since in daily practice the diagnosis of CNS-PTLD is often not initially considered when present due to its rarity and the lack of radiologists’ familiarity with the disease. Conclusion: Knowing the unique imaging features of CNS-PTLD narrows the differential diagnosis, facilitates the diagnostic work-up, and optimizes making the diagnosis. Advanced MRI data for CNS PTLD is limited but is promising for helping with narrowing the differential diagnosis.

AB - Objective: Central nervous system post-transplant lymphoproliferative disorder (CNS-PTLD) is a rare disease that presents with non-specific signs and symptoms. The purpose of this article is to present the imaging appearances of CNS-PTLD by magnetic resonance imaging. We highlight the differential diagnostic considerations including primary central nervous system lymphoma, glioblastoma, cerebral abscess, and metastatic disease. This is an important topic to review since in daily practice the diagnosis of CNS-PTLD is often not initially considered when present due to its rarity and the lack of radiologists’ familiarity with the disease. Conclusion: Knowing the unique imaging features of CNS-PTLD narrows the differential diagnosis, facilitates the diagnostic work-up, and optimizes making the diagnosis. Advanced MRI data for CNS PTLD is limited but is promising for helping with narrowing the differential diagnosis.

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