Primary Carcinoid Tumor of the Renal Pelvis Arising from Intestinal Metaplasia: An Unusual Histogenetic Pathway?

Maria G. Kuba, Allison Wasserman, Cindy L. Vnencak-Jones, Julia A. Bridge, Lan Gellert, Omar Hameed, Giovanna A. Giannico

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Primary carcinoid tumor of the renal pelvis is a rare neoplasm with few cases reported in the literature. Here we present the clinical and histopathologic findings of a primary carcinoid tumor arising in the left renal pelvis of a horseshoe kidney in a 61-year-old female patient. Materials and Methods: Pathologic features were evaluated with standard hematoxylin and eosin sections and immunohistochemical studies. A literature review was performed to place our case in context to previous reports. Results: The tumor was associated with intestinal metaplasia with high-grade dysplasia and neuroendocrine hyperplasia. Molecular testing for microsatellite instability and loss of heterozygosity were negative. Conclusions: This report portrays a unique presentation of carcinoid tumor arising from intestinal metaplasia of the pelvic urothelium, and supports its histogenesis from urothelial intestinal metaplasia and neuroendocrine hyperplasia.

Original languageEnglish (US)
Pages (from-to)e49-e57
JournalApplied Immunohistochemistry and Molecular Morphology
Volume25
Issue number7
DOIs
StatePublished - Jan 1 2017

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Kidney Pelvis
Carcinoid Tumor
Metaplasia
Hyperplasia
Urothelium
Microsatellite Instability
Loss of Heterozygosity
Hematoxylin
Eosine Yellowish-(YS)
Neoplasms

Keywords

  • intestinal metaplasia
  • kidney
  • neuroendocrine tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

Cite this

Primary Carcinoid Tumor of the Renal Pelvis Arising from Intestinal Metaplasia : An Unusual Histogenetic Pathway? / Kuba, Maria G.; Wasserman, Allison; Vnencak-Jones, Cindy L.; Bridge, Julia A.; Gellert, Lan; Hameed, Omar; Giannico, Giovanna A.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 25, No. 7, 01.01.2017, p. e49-e57.

Research output: Contribution to journalArticle

Kuba, Maria G. ; Wasserman, Allison ; Vnencak-Jones, Cindy L. ; Bridge, Julia A. ; Gellert, Lan ; Hameed, Omar ; Giannico, Giovanna A. / Primary Carcinoid Tumor of the Renal Pelvis Arising from Intestinal Metaplasia : An Unusual Histogenetic Pathway?. In: Applied Immunohistochemistry and Molecular Morphology. 2017 ; Vol. 25, No. 7. pp. e49-e57.
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