Prevention of stress-induced erosive gastritis by parenteral administration of arachidonic acid

L. J. Auguste, R. Lackner, L. Ratner, T. A. Stein, B. Bailey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Stress-induced mucosal ulcerations are associated with a decreased synthesis of mucosal prostaglandin (PG) E2. This phenomenon is poorly understood. To investigate whether it is due to a decreased availability of the necessary substrates to the mucosa, four groups of 10 Holtzman rats were studied: group 1 received normal saline by intraperitoneal (ip) injection; group 2 also received ip normal saline, then were submitted to stress, by the cold restraint method; group 3 received a solution of arachidonic acid (AA) ip; and group 4 also received ip AA, then were submitted to stress. After sacrifice, the number of gastric ulcerations were counted and specimens of nonulcerated mucosa were assayed for PGE2 by high-performance liquid chromatography; the mean numbers of ulcers were 0, 5.8, 0.8, and 3 and the mean levels of PGE2 were 55, 41, 125, and 62 pg/mg of wet tissue for groups 1, 2, 3, and 4, respectively. It is concluded that parenteral administration of AA reduces but does not completely eliminate stress-induced gastric ulcerations and that the stressed animals synthesized half as much PGE2 as the nonstressed ones after ip administration of equal amounts of AA, suggesting that stress reduces the availability of AA to the gastric mucosa, possibly by vascular spasm.

Original languageEnglish (US)
Pages (from-to)615-617
Number of pages3
JournalJournal of Parenteral and Enteral Nutrition
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1990

Fingerprint

gastritis
Gastritis
arachidonic acid
Arachidonic Acid
Dinoprostone
intraperitoneal injection
mucosa
Stomach
Mucous Membrane
stomach
gastric mucosa
Spasm
Gastric Mucosa
Intraperitoneal Injections
blood vessels
prostaglandins
Ulcer
Blood Vessels
Sprague Dawley Rats
high performance liquid chromatography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Prevention of stress-induced erosive gastritis by parenteral administration of arachidonic acid. / Auguste, L. J.; Lackner, R.; Ratner, L.; Stein, T. A.; Bailey, B.

In: Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 6, 01.01.1990, p. 615-617.

Research output: Contribution to journalArticle

@article{7b13b83da837436a9105f796c9bb951d,
title = "Prevention of stress-induced erosive gastritis by parenteral administration of arachidonic acid",
abstract = "Stress-induced mucosal ulcerations are associated with a decreased synthesis of mucosal prostaglandin (PG) E2. This phenomenon is poorly understood. To investigate whether it is due to a decreased availability of the necessary substrates to the mucosa, four groups of 10 Holtzman rats were studied: group 1 received normal saline by intraperitoneal (ip) injection; group 2 also received ip normal saline, then were submitted to stress, by the cold restraint method; group 3 received a solution of arachidonic acid (AA) ip; and group 4 also received ip AA, then were submitted to stress. After sacrifice, the number of gastric ulcerations were counted and specimens of nonulcerated mucosa were assayed for PGE2 by high-performance liquid chromatography; the mean numbers of ulcers were 0, 5.8, 0.8, and 3 and the mean levels of PGE2 were 55, 41, 125, and 62 pg/mg of wet tissue for groups 1, 2, 3, and 4, respectively. It is concluded that parenteral administration of AA reduces but does not completely eliminate stress-induced gastric ulcerations and that the stressed animals synthesized half as much PGE2 as the nonstressed ones after ip administration of equal amounts of AA, suggesting that stress reduces the availability of AA to the gastric mucosa, possibly by vascular spasm.",
author = "Auguste, {L. J.} and R. Lackner and L. Ratner and Stein, {T. A.} and B. Bailey",
year = "1990",
month = "1",
day = "1",
doi = "10.1177/0148607190014006615",
language = "English (US)",
volume = "14",
pages = "615--617",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Prevention of stress-induced erosive gastritis by parenteral administration of arachidonic acid

AU - Auguste, L. J.

AU - Lackner, R.

AU - Ratner, L.

AU - Stein, T. A.

AU - Bailey, B.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Stress-induced mucosal ulcerations are associated with a decreased synthesis of mucosal prostaglandin (PG) E2. This phenomenon is poorly understood. To investigate whether it is due to a decreased availability of the necessary substrates to the mucosa, four groups of 10 Holtzman rats were studied: group 1 received normal saline by intraperitoneal (ip) injection; group 2 also received ip normal saline, then were submitted to stress, by the cold restraint method; group 3 received a solution of arachidonic acid (AA) ip; and group 4 also received ip AA, then were submitted to stress. After sacrifice, the number of gastric ulcerations were counted and specimens of nonulcerated mucosa were assayed for PGE2 by high-performance liquid chromatography; the mean numbers of ulcers were 0, 5.8, 0.8, and 3 and the mean levels of PGE2 were 55, 41, 125, and 62 pg/mg of wet tissue for groups 1, 2, 3, and 4, respectively. It is concluded that parenteral administration of AA reduces but does not completely eliminate stress-induced gastric ulcerations and that the stressed animals synthesized half as much PGE2 as the nonstressed ones after ip administration of equal amounts of AA, suggesting that stress reduces the availability of AA to the gastric mucosa, possibly by vascular spasm.

AB - Stress-induced mucosal ulcerations are associated with a decreased synthesis of mucosal prostaglandin (PG) E2. This phenomenon is poorly understood. To investigate whether it is due to a decreased availability of the necessary substrates to the mucosa, four groups of 10 Holtzman rats were studied: group 1 received normal saline by intraperitoneal (ip) injection; group 2 also received ip normal saline, then were submitted to stress, by the cold restraint method; group 3 received a solution of arachidonic acid (AA) ip; and group 4 also received ip AA, then were submitted to stress. After sacrifice, the number of gastric ulcerations were counted and specimens of nonulcerated mucosa were assayed for PGE2 by high-performance liquid chromatography; the mean numbers of ulcers were 0, 5.8, 0.8, and 3 and the mean levels of PGE2 were 55, 41, 125, and 62 pg/mg of wet tissue for groups 1, 2, 3, and 4, respectively. It is concluded that parenteral administration of AA reduces but does not completely eliminate stress-induced gastric ulcerations and that the stressed animals synthesized half as much PGE2 as the nonstressed ones after ip administration of equal amounts of AA, suggesting that stress reduces the availability of AA to the gastric mucosa, possibly by vascular spasm.

UR - http://www.scopus.com/inward/record.url?scp=0025245524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025245524&partnerID=8YFLogxK

U2 - 10.1177/0148607190014006615

DO - 10.1177/0148607190014006615

M3 - Article

C2 - 2125645

AN - SCOPUS:0025245524

VL - 14

SP - 615

EP - 617

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

IS - 6

ER -