Prevention of Contraction of Patched Intestinal Defects

Jon S Thompson, T. C. Hollingsed, S. K. Saxena

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Neomucosal growth on a serosal patch might increase intestinal surface area in the short-bowel syndrome but is limited by contraction of the patched defect. Our aim was to reduce contraction by mechanical or pharmacologic means. Ileal defects (2×5 cm) were patched with colon serosa in 14 rabbits. Group 1 (n=5) had a plastic splint sutured to the defect edge. Group 2 (n=4) received hydrocortisone acetate and vitamin A. Group 3 (n=5) was the control group. Four weeks after patching there was significantly less contraction in groups 1 and 2 compared with group 3 (72.3%±5.6% and 50.0%±5.8% vs 31.9%±1.8% initial defect size). Epithelial coverage of the defect was greater in groups 1 and 3 than in group 2. Disaccharidase activity of neomucosa and surrounding mucosa was significantly decreased in the steroid-treated rabbits. Contraction of a serosal patch can be reduced by mechanical and pharmacologic measures that may enhance the clinical applicability of this technique.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalArchives of Surgery
Volume123
Issue number4
DOIs
StatePublished - Jan 1 1988

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hydrocortisone acetate
Disaccharidases
Rabbits
Short Bowel Syndrome
Serous Membrane
Splints
Vitamin A
Plastics
Colon
Mucous Membrane
Steroids
Control Groups
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

Prevention of Contraction of Patched Intestinal Defects. / Thompson, Jon S; Hollingsed, T. C.; Saxena, S. K.

In: Archives of Surgery, Vol. 123, No. 4, 01.01.1988, p. 428-430.

Research output: Contribution to journalArticle

Thompson, Jon S ; Hollingsed, T. C. ; Saxena, S. K. / Prevention of Contraction of Patched Intestinal Defects. In: Archives of Surgery. 1988 ; Vol. 123, No. 4. pp. 428-430.
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