Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity

Gail S. Kerr, Iraj Sabahi, John S. Richards, Liron Caplan, Grant W. Cannon, Andreas Reimold, Geoffrey Milton Thiele, Dannette Johnson, Ted R Mikuls

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Objective: 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. Methods: Vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. Results: Patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. Conclusion: In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalJournal of Rheumatology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Vitamin D Deficiency
Rheumatoid Arthritis
Vitamin D
Veterans
hydroxide ion
C-Reactive Protein
Radioimmunoassay
Chronic Disease
Joints
Logistic Models
Antibodies
Health
Population

Keywords

  • 25-hydroxyl-vitamin D
  • Anti-cyclic citrullinated peptide
  • Rheumatoid arthritis
  • US veterans

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. / Kerr, Gail S.; Sabahi, Iraj; Richards, John S.; Caplan, Liron; Cannon, Grant W.; Reimold, Andreas; Thiele, Geoffrey Milton; Johnson, Dannette; Mikuls, Ted R.

In: Journal of Rheumatology, Vol. 38, No. 1, 01.01.2011, p. 53-59.

Research output: Contribution to journalArticle

Kerr, Gail S. ; Sabahi, Iraj ; Richards, John S. ; Caplan, Liron ; Cannon, Grant W. ; Reimold, Andreas ; Thiele, Geoffrey Milton ; Johnson, Dannette ; Mikuls, Ted R. / Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. In: Journal of Rheumatology. 2011 ; Vol. 38, No. 1. pp. 53-59.
@article{99278127e11a4aaeb3dd5ab4e7243c62,
title = "Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity",
abstract = "Objective: 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. Methods: Vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. Results: Patients (850 men, 76{\%} Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84{\%} and 43{\%}, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. Conclusion: In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.",
keywords = "25-hydroxyl-vitamin D, Anti-cyclic citrullinated peptide, Rheumatoid arthritis, US veterans",
author = "Kerr, {Gail S.} and Iraj Sabahi and Richards, {John S.} and Liron Caplan and Cannon, {Grant W.} and Andreas Reimold and Thiele, {Geoffrey Milton} and Dannette Johnson and Mikuls, {Ted R}",
year = "2011",
month = "1",
day = "1",
doi = "10.3899/jrheum.100516",
language = "English (US)",
volume = "38",
pages = "53--59",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "1",

}

TY - JOUR

T1 - Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity

AU - Kerr, Gail S.

AU - Sabahi, Iraj

AU - Richards, John S.

AU - Caplan, Liron

AU - Cannon, Grant W.

AU - Reimold, Andreas

AU - Thiele, Geoffrey Milton

AU - Johnson, Dannette

AU - Mikuls, Ted R

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. Methods: Vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. Results: Patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. Conclusion: In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.

AB - Objective: 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. Methods: Vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. Results: Patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. Conclusion: In a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.

KW - 25-hydroxyl-vitamin D

KW - Anti-cyclic citrullinated peptide

KW - Rheumatoid arthritis

KW - US veterans

UR - http://www.scopus.com/inward/record.url?scp=78650863958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650863958&partnerID=8YFLogxK

U2 - 10.3899/jrheum.100516

DO - 10.3899/jrheum.100516

M3 - Article

VL - 38

SP - 53

EP - 59

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 1

ER -