Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: The impact of ethnic-specific normative data

Ted R. Mikuls, Kenneth G. Saag, Jeffrey Curtis, S. Louis Bridges, Graciela S. Alarcon, Andrew O. Westfall, Sam S. Lim, Edwin A. Smith, Beth L. Jonas, Larry W. Moreland

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Purpose: To examine the prevalence of osteopenia and/or osteoporosis among African Americans with early rheumatoid arthritis (RA) and to assess the effect of using race/ethnicity-specific normative data. Methods: Bone mineral density (BMD) of the hip and spine was assessed in African Americans with early RA. To examine the impact of using different normative data on disease classification, we calculated two sets of T scores, the first using sex-matched reference data from Caucasians and the second using data from African Americans. Osteoporosis was defined as a BMD at either site ≥2.5 SD below the young adult mean. Osteopenia was defined as a BMD ≥1 SD and <2.5 SD below this mean. Results: Using Caucasian referent data, 33% (n=48) of patients had osteopenia or worse (n=48, 32.9%) and 5% (n=8) were osteoporotic. With the use of African-American normative data, 55% (n=94) were osteopenic or worse, and 16% (n=27) were osteoporotic. Conclusion: African Americans with RA are at risk of osteopenia and/or osteoporosis. Different diagnostic classifications may occur in this population based solely on the normative data used for assessing fracture risk. These results underscore the need for a standardized approach in defining osteopenia and osteoporosis in African Americans.

Original languageEnglish (US)
Pages (from-to)1155-1160
Number of pages6
JournalJournal of the National Medical Association
Volume97
Issue number8
StatePublished - Aug 1 2005

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Keywords

  • African Americans
  • DXA
  • Osteopenia
  • Osteoporosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mikuls, T. R., Saag, K. G., Curtis, J., Bridges, S. L., Alarcon, G. S., Westfall, A. O., Lim, S. S., Smith, E. A., Jonas, B. L., & Moreland, L. W. (2005). Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: The impact of ethnic-specific normative data. Journal of the National Medical Association, 97(8), 1155-1160.