Prevalence of metabolic syndrome in COPD patients and its consequences

Marie Kathrin Breyer, Martijn A. Spruit, Corrine K Hanson, Frits M E Franssen, Lowie E G W Vanfleteren, Miriam T J Groenen, Piet L B Bruijnzeel, Emiel F M Wouters, Erica P A Rutten

Research output: Contribution to journalArticle

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Abstract

Background: The prevalence of metabolic syndrome in COPD patients and its impact on patient related outcomes has been little studied. We evaluated the prevalence of metabolic syndrome and clinical and functional characteristics in patients with COPD and healthy subjects. Methods: 228 COPD patients and 156 healthy subjects were included. Metabolic syndrome was defined using criteria of the IDF. In all patients spirometry, body composition, functional exercise performance, and mood and health status were assessed. Groups were stratified for BMI and gender. Results: Metabolic syndrome was present in 57% of the COPD patients and 40% of the healthy subjects. After stratification for BMI, presence of metabolic syndrome in patients with a BMI ≥25 kg/m2 was higher than in healthy peers. Patients with metabolic syndrome and a BMI <25 kg/m2 had higher BMI, fat free mass index and bone mineral density, and a lower 6MWD than the BMI matched patients without metabolic syndrome. Spirometry, maximal ergometry, mood and health status, and blood gases were not different between those groups. In COPD patients with metabolic syndrome self-reported co-morbidities and medication use were higher than in those without. Conclusion: Metabolic syndrome is more prevalent in overweight or obese COPD patients than in BMI matched healthy subjects. Metabolic syndrome did not additionally impact patients' functional outcomes, but did impact the prevalence of co-morbidities.

Original languageEnglish (US)
Article numbere98013
JournalPloS one
Volume9
Issue number6
DOIs
StatePublished - Jun 20 2014

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metabolic syndrome
Chronic Obstructive Pulmonary Disease
Health
Minerals
Bone
Blood
Gases
Fats
Healthy Volunteers
Chemical analysis
Spirometry
emotions
health status
Health Status
Morbidity
Ergometry
bone density
blood gases
peers
Body Composition

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Breyer, M. K., Spruit, M. A., Hanson, C. K., Franssen, F. M. E., Vanfleteren, L. E. G. W., Groenen, M. T. J., ... Rutten, E. P. A. (2014). Prevalence of metabolic syndrome in COPD patients and its consequences. PloS one, 9(6), [e98013]. https://doi.org/10.1371/journal.pone.0098013

Prevalence of metabolic syndrome in COPD patients and its consequences. / Breyer, Marie Kathrin; Spruit, Martijn A.; Hanson, Corrine K; Franssen, Frits M E; Vanfleteren, Lowie E G W; Groenen, Miriam T J; Bruijnzeel, Piet L B; Wouters, Emiel F M; Rutten, Erica P A.

In: PloS one, Vol. 9, No. 6, e98013, 20.06.2014.

Research output: Contribution to journalArticle

Breyer, MK, Spruit, MA, Hanson, CK, Franssen, FME, Vanfleteren, LEGW, Groenen, MTJ, Bruijnzeel, PLB, Wouters, EFM & Rutten, EPA 2014, 'Prevalence of metabolic syndrome in COPD patients and its consequences', PloS one, vol. 9, no. 6, e98013. https://doi.org/10.1371/journal.pone.0098013
Breyer MK, Spruit MA, Hanson CK, Franssen FME, Vanfleteren LEGW, Groenen MTJ et al. Prevalence of metabolic syndrome in COPD patients and its consequences. PloS one. 2014 Jun 20;9(6). e98013. https://doi.org/10.1371/journal.pone.0098013
Breyer, Marie Kathrin ; Spruit, Martijn A. ; Hanson, Corrine K ; Franssen, Frits M E ; Vanfleteren, Lowie E G W ; Groenen, Miriam T J ; Bruijnzeel, Piet L B ; Wouters, Emiel F M ; Rutten, Erica P A. / Prevalence of metabolic syndrome in COPD patients and its consequences. In: PloS one. 2014 ; Vol. 9, No. 6.
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