Prenatal X-ray exposure and rhabdomyosarcoma in children

A report from the children's oncology group

Seymour Grufferman, Frederick Ruymann, Simona Ognjanovic, Erik B. Erhardt, Harold Maurice Maurer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The association between antenatal diagnostic X-ray exposure and risk of rhabdomyosarcoma in children was assessed in a national case-control study of 319 rhabdomyosarcoma cases and 319 matched controls. Data were collected by telephone interviews of subjects' parents. Overall, an odds ratio (OR) of 1.9 [95% confidence interval(CI), 1.1-3.4] was found for any X-ray examination of the mother during pregnancy. Risk was greatest for X-ray exposure during the first trimester (OR, 5.7; 95% CI, 1.2-27.8) and was also increased for the third trimester (OR, 2.0; 95% CI, 0.9-4.6), whereas second trimester exposure was not associated with increased risk. A nonsignificant increase in risk was found for any X-rays of the abdomen, pelvis, chest, or back. Increased risk was significantly associated with "other" X-ray exposures (relative risk, 2.9; 95% CI, 1.1-7.7), primarily composed of dental X-rays. The association was strongest between embryonal rhabdomyosarcoma and first trimester exposure (relative risk, 10.5; 95% CI, 1.5-458.4). This observation regarding embryonal rhabdomyosarcoma, and our previous report of an increased frequency of major malformations in rhabdomyosarcoma are compatible with findings from animal studies in which Ptc heterozygous knockout mice exhibited an increased risk of radiation-induced development defects and of spontaneously occurring embryonal rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)1271-1276
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number4
DOIs
StatePublished - Apr 1 2009

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Rhabdomyosarcoma
X-Rays
Embryonal Rhabdomyosarcoma
Confidence Intervals
Odds Ratio
First Pregnancy Trimester
Third Pregnancy Trimester
Second Pregnancy Trimester
Pelvis
Knockout Mice
Radiography
Abdomen
Case-Control Studies
Tooth
Thorax
Parents
Mothers
Interviews
Radiation
Pregnancy

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Prenatal X-ray exposure and rhabdomyosarcoma in children : A report from the children's oncology group. / Grufferman, Seymour; Ruymann, Frederick; Ognjanovic, Simona; Erhardt, Erik B.; Maurer, Harold Maurice.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 4, 01.04.2009, p. 1271-1276.

Research output: Contribution to journalArticle

Grufferman, Seymour ; Ruymann, Frederick ; Ognjanovic, Simona ; Erhardt, Erik B. ; Maurer, Harold Maurice. / Prenatal X-ray exposure and rhabdomyosarcoma in children : A report from the children's oncology group. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 4. pp. 1271-1276.
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