Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats

Yiu K. Fung, J. A. Reed, Yuen Sum Lau

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

Original languageEnglish (US)
Pages (from-to)689-693
Number of pages5
JournalGeneral Pharmacology
Volume20
Issue number5
DOIs
StatePublished - 1989

Fingerprint

Corpus Striatum
Cocaine
Dopamine Receptors
Locomotion

ASJC Scopus subject areas

  • Pharmacology

Cite this

Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats. / Fung, Yiu K.; Reed, J. A.; Lau, Yuen Sum.

In: General Pharmacology, Vol. 20, No. 5, 1989, p. 689-693.

Research output: Contribution to journalArticle

@article{bddac1c2d7614c5597a8bf4754d11452,
title = "Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats",
abstract = "1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.",
author = "Fung, {Yiu K.} and Reed, {J. A.} and Lau, {Yuen Sum}",
year = "1989",
doi = "10.1016/0306-3623(89)90108-0",
language = "English (US)",
volume = "20",
pages = "689--693",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats

AU - Fung, Yiu K.

AU - Reed, J. A.

AU - Lau, Yuen Sum

PY - 1989

Y1 - 1989

N2 - 1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

AB - 1. 1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. 3. No change in the characteristics of dopaminergic receptors and the rate of dopamine turnover was detected in the striatum.

UR - http://www.scopus.com/inward/record.url?scp=0024456392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024456392&partnerID=8YFLogxK

U2 - 10.1016/0306-3623(89)90108-0

DO - 10.1016/0306-3623(89)90108-0

M3 - Article

C2 - 2606336

AN - SCOPUS:0024456392

VL - 20

SP - 689

EP - 693

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 5

ER -