Preliminary Evaluation of the Viability of Peritoneal Drainage Catheters Implanted in Rats for Extended Durations

Nathan Legband, Arielle Black, Craig Kreikemeier-Bower, Benjamin S Terry

Research output: Contribution to journalArticle

Abstract

Purpose/Aim: In developing a novel peritoneal oxygenation therapy, catheters implanted into the peritoneal cavity became obstructed with omental tissue and prevented the infusion and removal of fluid from the peritoneal cavity. The obstruction of peritoneal catheters is a significant failure in researching various peritoneal treatments as further fluid administration is no longer possible. The purpose of this preliminary study was to determine the most effective catheter design for infusion and removal of fluid into the peritoneal cavity of rats. Materials and Methods: Four types of catheters were tested including the Jackson-Pratt, round fluted drain, flat fluted drain, and an original design. Three of each catheter type were surgically placed into the peritoneal cavity of rats (n = 12). In order to test the efficacy of each catheter, saline was infused and extracted twice daily. Catheters were scored on a weighted scale based on the amount of time they remained patent, the subjective force needed for extraction/infusion, and the amount of saline removed. Results: The round and flat fluted drain catheters remained patent for the full duration of the study (12 days) compared to the other models which failed after 7 days. These catheters also yielded a high average for extracted saline volume and an easy extraction/infusion. Conclusions: The round and flat fluted drain catheters were recognized as viable options to be used in rats for peritoneal drain studies of up to 12 days.

Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalJournal of Investigative Surgery
Volume32
Issue number4
DOIs
StatePublished - May 19 2019

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Drainage
Catheters
Peritoneal Cavity
Catheter Obstruction
Therapeutics

Keywords

  • Jackson-Pratt
  • abdominal surgery
  • animal model
  • catheter blockage
  • long term patency
  • peritoneal drainage

ASJC Scopus subject areas

  • Surgery

Cite this

Preliminary Evaluation of the Viability of Peritoneal Drainage Catheters Implanted in Rats for Extended Durations. / Legband, Nathan; Black, Arielle; Kreikemeier-Bower, Craig; Terry, Benjamin S.

In: Journal of Investigative Surgery, Vol. 32, No. 4, 19.05.2019, p. 321-330.

Research output: Contribution to journalArticle

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