Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats

Jamie L. Wilkinson, Matthew I. Palmatier, Rick A Bevins

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Little is known about the interaction between nicotine and bupropion (Zyban), but many studies suggest they have neurological and behavioral similarities. One feature of drugs with common profiles is the ability to cross-sensitize possibly through neurological changes in the reward pathway. Activation of this pathway might explain the effectiveness of bupropion as a smoking cessation aid. The present research investigated whether repeated nicotine administration altered the subsequent locomotor effects of bupropion. In experiment 1, rats were preexposed to nicotine (0.4mg/kg subcutaneously) or saline on eight separate occasions in the home cage and then tested with bupropion (0, 20, or 30mg/kg) in locomotor chambers. The acute stimulant effect of 30mg/kg of bupropion was potentiated by nicotine preexposure. In experiment 2, rats received nicotine repeatedly paired with the locomotor chambers or home cages. An additive effect was observed between acute bupropion and nicotine-conditioned hyperactivity in the chamber-paired group. This enhancement of the acute locomotor effects of bupropion might reflect alterations in common dopaminergic processes.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalNicotine and Tobacco Research
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2006

Fingerprint

Bupropion
Nicotine
Aptitude
Smoking Cessation
Reward
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats. / Wilkinson, Jamie L.; Palmatier, Matthew I.; Bevins, Rick A.

In: Nicotine and Tobacco Research, Vol. 8, No. 1, 01.02.2006, p. 141-146.

Research output: Contribution to journalArticle

@article{09eb15d01d154cc9a7f763f39f3af980,
title = "Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats",
abstract = "Little is known about the interaction between nicotine and bupropion (Zyban), but many studies suggest they have neurological and behavioral similarities. One feature of drugs with common profiles is the ability to cross-sensitize possibly through neurological changes in the reward pathway. Activation of this pathway might explain the effectiveness of bupropion as a smoking cessation aid. The present research investigated whether repeated nicotine administration altered the subsequent locomotor effects of bupropion. In experiment 1, rats were preexposed to nicotine (0.4mg/kg subcutaneously) or saline on eight separate occasions in the home cage and then tested with bupropion (0, 20, or 30mg/kg) in locomotor chambers. The acute stimulant effect of 30mg/kg of bupropion was potentiated by nicotine preexposure. In experiment 2, rats received nicotine repeatedly paired with the locomotor chambers or home cages. An additive effect was observed between acute bupropion and nicotine-conditioned hyperactivity in the chamber-paired group. This enhancement of the acute locomotor effects of bupropion might reflect alterations in common dopaminergic processes.",
author = "Wilkinson, {Jamie L.} and Palmatier, {Matthew I.} and Bevins, {Rick A}",
year = "2006",
month = "2",
day = "1",
doi = "10.1080/14622200500484642",
language = "English (US)",
volume = "8",
pages = "141--146",
journal = "Nicotine and Tobacco Research",
issn = "1462-2203",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats

AU - Wilkinson, Jamie L.

AU - Palmatier, Matthew I.

AU - Bevins, Rick A

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Little is known about the interaction between nicotine and bupropion (Zyban), but many studies suggest they have neurological and behavioral similarities. One feature of drugs with common profiles is the ability to cross-sensitize possibly through neurological changes in the reward pathway. Activation of this pathway might explain the effectiveness of bupropion as a smoking cessation aid. The present research investigated whether repeated nicotine administration altered the subsequent locomotor effects of bupropion. In experiment 1, rats were preexposed to nicotine (0.4mg/kg subcutaneously) or saline on eight separate occasions in the home cage and then tested with bupropion (0, 20, or 30mg/kg) in locomotor chambers. The acute stimulant effect of 30mg/kg of bupropion was potentiated by nicotine preexposure. In experiment 2, rats received nicotine repeatedly paired with the locomotor chambers or home cages. An additive effect was observed between acute bupropion and nicotine-conditioned hyperactivity in the chamber-paired group. This enhancement of the acute locomotor effects of bupropion might reflect alterations in common dopaminergic processes.

AB - Little is known about the interaction between nicotine and bupropion (Zyban), but many studies suggest they have neurological and behavioral similarities. One feature of drugs with common profiles is the ability to cross-sensitize possibly through neurological changes in the reward pathway. Activation of this pathway might explain the effectiveness of bupropion as a smoking cessation aid. The present research investigated whether repeated nicotine administration altered the subsequent locomotor effects of bupropion. In experiment 1, rats were preexposed to nicotine (0.4mg/kg subcutaneously) or saline on eight separate occasions in the home cage and then tested with bupropion (0, 20, or 30mg/kg) in locomotor chambers. The acute stimulant effect of 30mg/kg of bupropion was potentiated by nicotine preexposure. In experiment 2, rats received nicotine repeatedly paired with the locomotor chambers or home cages. An additive effect was observed between acute bupropion and nicotine-conditioned hyperactivity in the chamber-paired group. This enhancement of the acute locomotor effects of bupropion might reflect alterations in common dopaminergic processes.

UR - http://www.scopus.com/inward/record.url?scp=33644606383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644606383&partnerID=8YFLogxK

U2 - 10.1080/14622200500484642

DO - 10.1080/14622200500484642

M3 - Article

VL - 8

SP - 141

EP - 146

JO - Nicotine and Tobacco Research

JF - Nicotine and Tobacco Research

SN - 1462-2203

IS - 1

ER -