Prediction of restenosis after coronary angioplasty by use of a new index: TIMI frame count/minimal luminal diameter ratio

Goran Stankovic, Athanassios Manginas, Vassilis Voudris, Gregory Pavlides, George Athanassopoulos, Miodrag Ostojic, Dennis V. Cokkinos

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background - It has been shown recently that postangioplasty coronary flow reserve and the degree of residual stenosis have a modest predictive value for short- and long-term clinical outcomes after coronary angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative index of coronary blood flow. Its relationship with Doppler coronary flow velocity and clinical outcome after coronary angioplasty has not been fully clarified. The aim of this study was to identify clinical, angiographic, and functional predictors of clinical and angiographic restenosis after conventional coronary angioplasty. Methods and Results - We studied 70 consecutive patients in whom intracoronary Doppler flow-velocity measurements were performed before and after angioplasty. Patients were evaluated for restenosis by clinical follow-up, exercise stress test/201Tl scintigraphy, and follow-up angiography, which was performed at 10.5±10.3 months in 63 patients. According to the results of univariate analysis, a new index, postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created. Multivariate analysis revealed that CTFC/MLD ratio was the only independent predictor of angiographic (OR 2.02; 95% CI 1.37 to 2.97; P<0.0004) and clinical (OR 1.60; 95% CI 1.15 to 2.21; P<0.005) restenosis. The receiver operating characteristic curve area of this index was 79% for angiographic and 73% for clinical restenosis. The optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94 for clinical restenosis, respectively. Conclusions - Our data indicate that postangioplasty CTFC/MLD ratio, which incorporates both the angiographic and functional features of coronary lesions, is a reliable, objective, and inexpensive index for prediction of angiographic and clinical restenosis after conventional coronary angioplasty.

Original languageEnglish (US)
Pages (from-to)962-968
Number of pages7
JournalCirculation
Volume101
Issue number9
DOIs
StatePublished - Mar 7 2000

Fingerprint

Coronary Restenosis
Angioplasty
Exercise Test
ROC Curve
Radionuclide Imaging
Angiography
Pathologic Constriction
Multivariate Analysis

Keywords

  • Angioplasty
  • Blood flow
  • Coronary disease
  • Restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Prediction of restenosis after coronary angioplasty by use of a new index : TIMI frame count/minimal luminal diameter ratio. / Stankovic, Goran; Manginas, Athanassios; Voudris, Vassilis; Pavlides, Gregory; Athanassopoulos, George; Ostojic, Miodrag; Cokkinos, Dennis V.

In: Circulation, Vol. 101, No. 9, 07.03.2000, p. 962-968.

Research output: Contribution to journalArticle

Stankovic, G, Manginas, A, Voudris, V, Pavlides, G, Athanassopoulos, G, Ostojic, M & Cokkinos, DV 2000, 'Prediction of restenosis after coronary angioplasty by use of a new index: TIMI frame count/minimal luminal diameter ratio', Circulation, vol. 101, no. 9, pp. 962-968. https://doi.org/10.1161/01.CIR.101.9.962
Stankovic, Goran ; Manginas, Athanassios ; Voudris, Vassilis ; Pavlides, Gregory ; Athanassopoulos, George ; Ostojic, Miodrag ; Cokkinos, Dennis V. / Prediction of restenosis after coronary angioplasty by use of a new index : TIMI frame count/minimal luminal diameter ratio. In: Circulation. 2000 ; Vol. 101, No. 9. pp. 962-968.
@article{0148ecca60ef4ef789458b6980a2de0c,
title = "Prediction of restenosis after coronary angioplasty by use of a new index: TIMI frame count/minimal luminal diameter ratio",
abstract = "Background - It has been shown recently that postangioplasty coronary flow reserve and the degree of residual stenosis have a modest predictive value for short- and long-term clinical outcomes after coronary angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative index of coronary blood flow. Its relationship with Doppler coronary flow velocity and clinical outcome after coronary angioplasty has not been fully clarified. The aim of this study was to identify clinical, angiographic, and functional predictors of clinical and angiographic restenosis after conventional coronary angioplasty. Methods and Results - We studied 70 consecutive patients in whom intracoronary Doppler flow-velocity measurements were performed before and after angioplasty. Patients were evaluated for restenosis by clinical follow-up, exercise stress test/201Tl scintigraphy, and follow-up angiography, which was performed at 10.5±10.3 months in 63 patients. According to the results of univariate analysis, a new index, postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created. Multivariate analysis revealed that CTFC/MLD ratio was the only independent predictor of angiographic (OR 2.02; 95{\%} CI 1.37 to 2.97; P<0.0004) and clinical (OR 1.60; 95{\%} CI 1.15 to 2.21; P<0.005) restenosis. The receiver operating characteristic curve area of this index was 79{\%} for angiographic and 73{\%} for clinical restenosis. The optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94 for clinical restenosis, respectively. Conclusions - Our data indicate that postangioplasty CTFC/MLD ratio, which incorporates both the angiographic and functional features of coronary lesions, is a reliable, objective, and inexpensive index for prediction of angiographic and clinical restenosis after conventional coronary angioplasty.",
keywords = "Angioplasty, Blood flow, Coronary disease, Restenosis",
author = "Goran Stankovic and Athanassios Manginas and Vassilis Voudris and Gregory Pavlides and George Athanassopoulos and Miodrag Ostojic and Cokkinos, {Dennis V.}",
year = "2000",
month = "3",
day = "7",
doi = "10.1161/01.CIR.101.9.962",
language = "English (US)",
volume = "101",
pages = "962--968",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Prediction of restenosis after coronary angioplasty by use of a new index

T2 - TIMI frame count/minimal luminal diameter ratio

AU - Stankovic, Goran

AU - Manginas, Athanassios

AU - Voudris, Vassilis

AU - Pavlides, Gregory

AU - Athanassopoulos, George

AU - Ostojic, Miodrag

AU - Cokkinos, Dennis V.

PY - 2000/3/7

Y1 - 2000/3/7

N2 - Background - It has been shown recently that postangioplasty coronary flow reserve and the degree of residual stenosis have a modest predictive value for short- and long-term clinical outcomes after coronary angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative index of coronary blood flow. Its relationship with Doppler coronary flow velocity and clinical outcome after coronary angioplasty has not been fully clarified. The aim of this study was to identify clinical, angiographic, and functional predictors of clinical and angiographic restenosis after conventional coronary angioplasty. Methods and Results - We studied 70 consecutive patients in whom intracoronary Doppler flow-velocity measurements were performed before and after angioplasty. Patients were evaluated for restenosis by clinical follow-up, exercise stress test/201Tl scintigraphy, and follow-up angiography, which was performed at 10.5±10.3 months in 63 patients. According to the results of univariate analysis, a new index, postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created. Multivariate analysis revealed that CTFC/MLD ratio was the only independent predictor of angiographic (OR 2.02; 95% CI 1.37 to 2.97; P<0.0004) and clinical (OR 1.60; 95% CI 1.15 to 2.21; P<0.005) restenosis. The receiver operating characteristic curve area of this index was 79% for angiographic and 73% for clinical restenosis. The optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94 for clinical restenosis, respectively. Conclusions - Our data indicate that postangioplasty CTFC/MLD ratio, which incorporates both the angiographic and functional features of coronary lesions, is a reliable, objective, and inexpensive index for prediction of angiographic and clinical restenosis after conventional coronary angioplasty.

AB - Background - It has been shown recently that postangioplasty coronary flow reserve and the degree of residual stenosis have a modest predictive value for short- and long-term clinical outcomes after coronary angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative index of coronary blood flow. Its relationship with Doppler coronary flow velocity and clinical outcome after coronary angioplasty has not been fully clarified. The aim of this study was to identify clinical, angiographic, and functional predictors of clinical and angiographic restenosis after conventional coronary angioplasty. Methods and Results - We studied 70 consecutive patients in whom intracoronary Doppler flow-velocity measurements were performed before and after angioplasty. Patients were evaluated for restenosis by clinical follow-up, exercise stress test/201Tl scintigraphy, and follow-up angiography, which was performed at 10.5±10.3 months in 63 patients. According to the results of univariate analysis, a new index, postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created. Multivariate analysis revealed that CTFC/MLD ratio was the only independent predictor of angiographic (OR 2.02; 95% CI 1.37 to 2.97; P<0.0004) and clinical (OR 1.60; 95% CI 1.15 to 2.21; P<0.005) restenosis. The receiver operating characteristic curve area of this index was 79% for angiographic and 73% for clinical restenosis. The optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94 for clinical restenosis, respectively. Conclusions - Our data indicate that postangioplasty CTFC/MLD ratio, which incorporates both the angiographic and functional features of coronary lesions, is a reliable, objective, and inexpensive index for prediction of angiographic and clinical restenosis after conventional coronary angioplasty.

KW - Angioplasty

KW - Blood flow

KW - Coronary disease

KW - Restenosis

UR - http://www.scopus.com/inward/record.url?scp=0034057818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034057818&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.101.9.962

DO - 10.1161/01.CIR.101.9.962

M3 - Article

C2 - 10704161

AN - SCOPUS:0034057818

VL - 101

SP - 962

EP - 968

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 9

ER -