Pre-weaning carvedilol treatment in spontaneously hypertensive rats

Erika I Boesen, Gavin W. Lambert, Warwick P. Anderson, Michelle M. Kett

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hypertension in spontaneously hypertensive rats (SHR) has been permanently abolished by aggressive treatment regimens targeted against the sympathetic nervous system and adrenal medulla, initiated during the pre-weaning period (guanethidine and nerve growth factor antiserum combined with either adrenal demedullation or prazosin treatment). To investigate the components of the sympatho-adrenal system involved, we treated pre-weaning SHR with the combined α1- and β-adrenoceptor antagonist carvedilol (60 mg/kg/ day s.c.; postnatal days 1-21). Carvedilol treatment significantly blocked adrenoceptors during the treatment period, delayed development (eye opening), reduced growth, and reduced arterial pressure and heart rate. However, there was only modest attenuation of the subsequent development of hypertension at 10 weeks of age (mean arterial pressure 129.5±1.8 versus 136.1±1.6 mm Hg in vehicle-treated littermates; P<0.05). Thus pre-weaning carvedilol treatment slightly but significantly attenuated the development of SHR hypertension at 10 weeks, suggesting that the profound antihypertensive effects of pre-weaning sympatho-adrenal ablation are attributable to factors other than α1- and β-adrenoceptor-mediated effects of catecholamines during this period.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalEuropean Journal of Pharmacology
Volume486
Issue number2
DOIs
StatePublished - Feb 20 2004

Fingerprint

Inbred SHR Rats
Weaning
Adrenergic Receptors
Hypertension
Arterial Pressure
Guanethidine
Adrenal Medulla
Prazosin
Sympathetic Nervous System
Nerve Growth Factor
Antihypertensive Agents
Catecholamines
Immune Sera
Heart Rate
carvedilol
Growth

Keywords

  • Andrenoceptor antagonist
  • Spontaneously hypertensive rat (SHR)
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pre-weaning carvedilol treatment in spontaneously hypertensive rats. / Boesen, Erika I; Lambert, Gavin W.; Anderson, Warwick P.; Kett, Michelle M.

In: European Journal of Pharmacology, Vol. 486, No. 2, 20.02.2004, p. 183-188.

Research output: Contribution to journalArticle

Boesen, Erika I ; Lambert, Gavin W. ; Anderson, Warwick P. ; Kett, Michelle M. / Pre-weaning carvedilol treatment in spontaneously hypertensive rats. In: European Journal of Pharmacology. 2004 ; Vol. 486, No. 2. pp. 183-188.
@article{e6488b9aa04f4b65b90917b96e845143,
title = "Pre-weaning carvedilol treatment in spontaneously hypertensive rats",
abstract = "Hypertension in spontaneously hypertensive rats (SHR) has been permanently abolished by aggressive treatment regimens targeted against the sympathetic nervous system and adrenal medulla, initiated during the pre-weaning period (guanethidine and nerve growth factor antiserum combined with either adrenal demedullation or prazosin treatment). To investigate the components of the sympatho-adrenal system involved, we treated pre-weaning SHR with the combined α1- and β-adrenoceptor antagonist carvedilol (60 mg/kg/ day s.c.; postnatal days 1-21). Carvedilol treatment significantly blocked adrenoceptors during the treatment period, delayed development (eye opening), reduced growth, and reduced arterial pressure and heart rate. However, there was only modest attenuation of the subsequent development of hypertension at 10 weeks of age (mean arterial pressure 129.5±1.8 versus 136.1±1.6 mm Hg in vehicle-treated littermates; P<0.05). Thus pre-weaning carvedilol treatment slightly but significantly attenuated the development of SHR hypertension at 10 weeks, suggesting that the profound antihypertensive effects of pre-weaning sympatho-adrenal ablation are attributable to factors other than α1- and β-adrenoceptor-mediated effects of catecholamines during this period.",
keywords = "Andrenoceptor antagonist, Spontaneously hypertensive rat (SHR), Sympathetic nervous system",
author = "Boesen, {Erika I} and Lambert, {Gavin W.} and Anderson, {Warwick P.} and Kett, {Michelle M.}",
year = "2004",
month = "2",
day = "20",
doi = "10.1016/j.ejphar.2003.12.012",
language = "English (US)",
volume = "486",
pages = "183--188",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Pre-weaning carvedilol treatment in spontaneously hypertensive rats

AU - Boesen, Erika I

AU - Lambert, Gavin W.

AU - Anderson, Warwick P.

AU - Kett, Michelle M.

PY - 2004/2/20

Y1 - 2004/2/20

N2 - Hypertension in spontaneously hypertensive rats (SHR) has been permanently abolished by aggressive treatment regimens targeted against the sympathetic nervous system and adrenal medulla, initiated during the pre-weaning period (guanethidine and nerve growth factor antiserum combined with either adrenal demedullation or prazosin treatment). To investigate the components of the sympatho-adrenal system involved, we treated pre-weaning SHR with the combined α1- and β-adrenoceptor antagonist carvedilol (60 mg/kg/ day s.c.; postnatal days 1-21). Carvedilol treatment significantly blocked adrenoceptors during the treatment period, delayed development (eye opening), reduced growth, and reduced arterial pressure and heart rate. However, there was only modest attenuation of the subsequent development of hypertension at 10 weeks of age (mean arterial pressure 129.5±1.8 versus 136.1±1.6 mm Hg in vehicle-treated littermates; P<0.05). Thus pre-weaning carvedilol treatment slightly but significantly attenuated the development of SHR hypertension at 10 weeks, suggesting that the profound antihypertensive effects of pre-weaning sympatho-adrenal ablation are attributable to factors other than α1- and β-adrenoceptor-mediated effects of catecholamines during this period.

AB - Hypertension in spontaneously hypertensive rats (SHR) has been permanently abolished by aggressive treatment regimens targeted against the sympathetic nervous system and adrenal medulla, initiated during the pre-weaning period (guanethidine and nerve growth factor antiserum combined with either adrenal demedullation or prazosin treatment). To investigate the components of the sympatho-adrenal system involved, we treated pre-weaning SHR with the combined α1- and β-adrenoceptor antagonist carvedilol (60 mg/kg/ day s.c.; postnatal days 1-21). Carvedilol treatment significantly blocked adrenoceptors during the treatment period, delayed development (eye opening), reduced growth, and reduced arterial pressure and heart rate. However, there was only modest attenuation of the subsequent development of hypertension at 10 weeks of age (mean arterial pressure 129.5±1.8 versus 136.1±1.6 mm Hg in vehicle-treated littermates; P<0.05). Thus pre-weaning carvedilol treatment slightly but significantly attenuated the development of SHR hypertension at 10 weeks, suggesting that the profound antihypertensive effects of pre-weaning sympatho-adrenal ablation are attributable to factors other than α1- and β-adrenoceptor-mediated effects of catecholamines during this period.

KW - Andrenoceptor antagonist

KW - Spontaneously hypertensive rat (SHR)

KW - Sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=1242306190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242306190&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2003.12.012

DO - 10.1016/j.ejphar.2003.12.012

M3 - Article

VL - 486

SP - 183

EP - 188

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -