Potential of urinary metabolites for diagnosing multiple sclerosis

Teklab Gebregiworgis, Chandirasegaran Massilamany, Arunakumar Gangaplara, Sivasubramani Thulasingam, Venkata Kolli, Mark T. Werth, Eric D Dodds, David J Steffen, N R Jayagopala Reddy, Robert Powers

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A definitive diagnostic test for multiple sclerosis (MS) does not exist; instead physicians use a combination of medical history, magnetic resonance imaging, and cerebrospinal fluid analysis (CSF). Significant effort has been employed to identify biomarkers from CSF to facilitate MS diagnosis; however, none of the proposed biomarkers have been successful to date. Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Nevertheless, urinary metabolites have not been extensively explored as a source of biomarkers for MS. We demonstrate that urinary metabolites have significant promise for monitoring disease-progression, and response to treatment in MS patients. NMR analysis of urine permitted the identification of metabolites that differentiate experimental autoimmune encephalomyelitis (EAE)-mice (prototypic disease model for MS) from healthy and MS drug-treated EAE mice.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalACS Chemical Biology
Volume8
Issue number4
DOIs
StatePublished - Apr 19 2013

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Biomarkers
Metabolites
Multiple Sclerosis
Cerebrospinal fluid
Autoimmune Experimental Encephalomyelitis
Cerebrospinal Fluid
Magnetic resonance
Urine
Nuclear magnetic resonance
Imaging techniques
Routine Diagnostic Tests
Disease Progression
Monitoring
Magnetic Resonance Imaging
Pharmaceutical Preparations
Physicians

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Gebregiworgis, T., Massilamany, C., Gangaplara, A., Thulasingam, S., Kolli, V., Werth, M. T., ... Powers, R. (2013). Potential of urinary metabolites for diagnosing multiple sclerosis. ACS Chemical Biology, 8(4), 684-690. https://doi.org/10.1021/cb300673e

Potential of urinary metabolites for diagnosing multiple sclerosis. / Gebregiworgis, Teklab; Massilamany, Chandirasegaran; Gangaplara, Arunakumar; Thulasingam, Sivasubramani; Kolli, Venkata; Werth, Mark T.; Dodds, Eric D; Steffen, David J; Reddy, N R Jayagopala; Powers, Robert.

In: ACS Chemical Biology, Vol. 8, No. 4, 19.04.2013, p. 684-690.

Research output: Contribution to journalArticle

Gebregiworgis, T, Massilamany, C, Gangaplara, A, Thulasingam, S, Kolli, V, Werth, MT, Dodds, ED, Steffen, DJ, Reddy, NRJ & Powers, R 2013, 'Potential of urinary metabolites for diagnosing multiple sclerosis', ACS Chemical Biology, vol. 8, no. 4, pp. 684-690. https://doi.org/10.1021/cb300673e
Gebregiworgis T, Massilamany C, Gangaplara A, Thulasingam S, Kolli V, Werth MT et al. Potential of urinary metabolites for diagnosing multiple sclerosis. ACS Chemical Biology. 2013 Apr 19;8(4):684-690. https://doi.org/10.1021/cb300673e
Gebregiworgis, Teklab ; Massilamany, Chandirasegaran ; Gangaplara, Arunakumar ; Thulasingam, Sivasubramani ; Kolli, Venkata ; Werth, Mark T. ; Dodds, Eric D ; Steffen, David J ; Reddy, N R Jayagopala ; Powers, Robert. / Potential of urinary metabolites for diagnosing multiple sclerosis. In: ACS Chemical Biology. 2013 ; Vol. 8, No. 4. pp. 684-690.
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