Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery

Yan Wang, Ying Xie, David Oupicky

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.

Original languageEnglish (US)
JournalCurrent Pharmacology Reports
Volume2
Issue number1
DOIs
StatePublished - Feb 1 2016

    Fingerprint

Keywords

  • CXCR4
  • Cancer
  • Drug delivery
  • Gene delivery
  • Metastasis
  • Nanoparticles
  • siRNA delivery

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this