Potential for tumor therapy with iodine-125 labeled immunoglobulins

S. J. Adelstein, A. I. Kassis, Janina Baranowska-Kortylewicz, A. D. Van Den Abbeele, G. Mariani, S. Ito

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Because of the high intranuclear toxicity of Auger-electron emitters, the use of radioiodinated ( 123 I, 125 I) 5-iodo-2′-deoxyuridine (IUdR)-antibody conjugates for cancer therapy has been examined. The results have demonstrated that all the conditions necessary for labeling DNA in vivo are present: uptake of the radiolabeled immunoglobulin by target cells, its subsequent internalization, the degradation of the IUdR-protein conjugate by lysosomal enzymes, and the incorporation of the radionucleoside into DNA.

Original languageEnglish (US)
Pages (from-to)43-44
Number of pages2
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1991

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Idoxuridine
Iodine
Immunoglobulins
Deoxyuridine
DNA
Proteolysis
Neoplasms
Electrons
Antibodies
Enzymes
Therapeutics
lysosomal proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Potential for tumor therapy with iodine-125 labeled immunoglobulins. / Adelstein, S. J.; Kassis, A. I.; Baranowska-Kortylewicz, Janina; Van Den Abbeele, A. D.; Mariani, G.; Ito, S.

In: International Journal of Radiation Applications and Instrumentation., Vol. 18, No. 1, 01.01.1991, p. 43-44.

Research output: Contribution to journalArticle

Adelstein, S. J. ; Kassis, A. I. ; Baranowska-Kortylewicz, Janina ; Van Den Abbeele, A. D. ; Mariani, G. ; Ito, S. / Potential for tumor therapy with iodine-125 labeled immunoglobulins. In: International Journal of Radiation Applications and Instrumentation. 1991 ; Vol. 18, No. 1. pp. 43-44.
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