Potential contribution of VH gene replacement in immunity and disease.

Yanwen Liu, Run Fan, Song Zhou, Zhihong Yu, Zhixin Zhang

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

VH replacement occurs through RAG-mediated recombination between a cryptic recombination signal sequence (cRSS) presented in a rearranged VH gene and a 23-bp RSS from an upstream VH gene. VH replacement renews the entire VH coding region and extends the immunoglobulin heavy-chain (IgH) CDR3 regions preferentially with charged amino acids. VH replacement occurs in bone marrow-immature B cells and contributes significantly to the primary B-cell repertoire in humans. However, the biological significance of VH replacement is not clear. Our recent studies revealed elevated frequencies of VH replacement products in different autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome. Moreover, elevated frequencies of VH replacement products were also found in patients with human immunodeficiency virus or hepatitis C virus infections. These results provide the first clue that VH replacement contributes to autoimmune disease and antiviral immunity, and they also suggest a potential link between viral infection and autoimmune disease.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1062
DOIs
StatePublished - Jan 1 2005

Fingerprint

Virus Diseases
Autoimmune Diseases
Immunity
Genes
Viruses
Genetic Recombination
Cells
RSS
Immunoglobulin Heavy Chains
B-Lymphoid Precursor Cells
Protein Sorting Signals
Hepacivirus
Systemic Lupus Erythematosus
Antiviral Agents
Rheumatoid Arthritis
Bone
B-Lymphocytes
Bone Marrow
HIV
Amino Acids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Potential contribution of VH gene replacement in immunity and disease. / Liu, Yanwen; Fan, Run; Zhou, Song; Yu, Zhihong; Zhang, Zhixin.

In: Annals of the New York Academy of Sciences, Vol. 1062, 01.01.2005, p. 175-181.

Research output: Contribution to journalReview article

Liu, Yanwen ; Fan, Run ; Zhou, Song ; Yu, Zhihong ; Zhang, Zhixin. / Potential contribution of VH gene replacement in immunity and disease. In: Annals of the New York Academy of Sciences. 2005 ; Vol. 1062. pp. 175-181.
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