Potential application of low-dose doxycycline to treat periodontitis in post-menopausal women.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of this paper is two-fold: (1) to review the evidence that osteoporosis and post-menopausal estrogen deficiency are associated with progressive alveolar bone loss and an elevated risk of tooth loss; and (2) to propose the use of tetracyclines, specifically low-dose doxycycline (LDD) (and, perhaps in the future, the chemically modified tetracyclines), to mitigate alveolar bone loss in post-menopausal osteoporotic/osteopenic women. Design concepts for a randomized clinical trial to study the effects of LDD on progressive alveolar bone loss in this patient population are reviewed. Since osteoporosis affects over 20 million people in the United States, progressive alveolar bone loss in this patient group represents a potentially significant public health problem unique from common adult periodontitis. Stopping progressive alveolar bone loss is essential to prevent both tooth loss and micro-architectural deterioration of alveolar bone.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalAdvances in dental research
Volume12
Issue number2
StatePublished - Nov 1998

Fingerprint

Alveolar Bone Loss
Doxycycline
Periodontitis
Tooth Loss
Tetracyclines
Chronic Periodontitis
Postmenopausal Osteoporosis
Osteoporosis
Estrogens
Randomized Controlled Trials
Public Health
Bone and Bones
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{0b93810bb2674ca99b325911be757801,
title = "Potential application of low-dose doxycycline to treat periodontitis in post-menopausal women.",
abstract = "The purpose of this paper is two-fold: (1) to review the evidence that osteoporosis and post-menopausal estrogen deficiency are associated with progressive alveolar bone loss and an elevated risk of tooth loss; and (2) to propose the use of tetracyclines, specifically low-dose doxycycline (LDD) (and, perhaps in the future, the chemically modified tetracyclines), to mitigate alveolar bone loss in post-menopausal osteoporotic/osteopenic women. Design concepts for a randomized clinical trial to study the effects of LDD on progressive alveolar bone loss in this patient population are reviewed. Since osteoporosis affects over 20 million people in the United States, progressive alveolar bone loss in this patient group represents a potentially significant public health problem unique from common adult periodontitis. Stopping progressive alveolar bone loss is essential to prevent both tooth loss and micro-architectural deterioration of alveolar bone.",
author = "Payne, {Jeffrey B} and Reinhardt, {Richard A}",
year = "1998",
month = "11",
language = "English (US)",
volume = "12",
pages = "166--169",
journal = "Advances in dental research",
issn = "0895-9374",
publisher = "International Association for Dental Research",
number = "2",

}

TY - JOUR

T1 - Potential application of low-dose doxycycline to treat periodontitis in post-menopausal women.

AU - Payne, Jeffrey B

AU - Reinhardt, Richard A

PY - 1998/11

Y1 - 1998/11

N2 - The purpose of this paper is two-fold: (1) to review the evidence that osteoporosis and post-menopausal estrogen deficiency are associated with progressive alveolar bone loss and an elevated risk of tooth loss; and (2) to propose the use of tetracyclines, specifically low-dose doxycycline (LDD) (and, perhaps in the future, the chemically modified tetracyclines), to mitigate alveolar bone loss in post-menopausal osteoporotic/osteopenic women. Design concepts for a randomized clinical trial to study the effects of LDD on progressive alveolar bone loss in this patient population are reviewed. Since osteoporosis affects over 20 million people in the United States, progressive alveolar bone loss in this patient group represents a potentially significant public health problem unique from common adult periodontitis. Stopping progressive alveolar bone loss is essential to prevent both tooth loss and micro-architectural deterioration of alveolar bone.

AB - The purpose of this paper is two-fold: (1) to review the evidence that osteoporosis and post-menopausal estrogen deficiency are associated with progressive alveolar bone loss and an elevated risk of tooth loss; and (2) to propose the use of tetracyclines, specifically low-dose doxycycline (LDD) (and, perhaps in the future, the chemically modified tetracyclines), to mitigate alveolar bone loss in post-menopausal osteoporotic/osteopenic women. Design concepts for a randomized clinical trial to study the effects of LDD on progressive alveolar bone loss in this patient population are reviewed. Since osteoporosis affects over 20 million people in the United States, progressive alveolar bone loss in this patient group represents a potentially significant public health problem unique from common adult periodontitis. Stopping progressive alveolar bone loss is essential to prevent both tooth loss and micro-architectural deterioration of alveolar bone.

UR - http://www.scopus.com/inward/record.url?scp=0032196052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032196052&partnerID=8YFLogxK

M3 - Article

C2 - 1999125174

AN - SCOPUS:0032196052

VL - 12

SP - 166

EP - 169

JO - Advances in dental research

JF - Advances in dental research

SN - 0895-9374

IS - 2

ER -