6 Citations (Scopus)

Abstract

Background and Objectives: The objective of this study was to examine post-operative mortality for elderly pancreatic cancer patients treated with multi-modality therapy. Methods: Surveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy). Results: Among 4,105 patients who underwent pancreatectomy between 1991 and 2008, 1-year mortality (Odds Ratio [OR] = 0.71; P-value = 0.000; 95% Confidence Interval [CI]: 0.60–0.85) and 6-month mortality (OR = 0.44; P-value = 0.000; 95%CI: 0.35–0.53) following pancreatectomy were significantly lower in the group that underwent pancreatectomy with early adjuvant therapy. Late adjuvant therapy group also had lower 1 year (OR = 0.51; P-value = 0.000; 95%CI: 0.43–0.61) and 6 months (OR = 0.14; P-value = 0.000; 95%CI: 0.10–0.17) mortality, compared to surgery alone. Conclusions: Post-operative outcomes were better for patients treated with surgery with adjuvant therapy, with the late adjuvant therapy group having the best outcomes (lowest odds of 6 month and 1-year mortality following surgery). J. Surg. Oncol. 2017;115:158–163.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalJournal of Surgical Oncology
Volume115
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Medicare
Pancreatic Neoplasms
Epidemiology
Pancreatectomy
Mortality
Odds Ratio
Confidence Intervals
Group Psychotherapy
Therapeutics
Adjuvant Radiotherapy
Adjuvant Chemotherapy
Secondary Prevention

Keywords

  • adjuvant therapy
  • outcomes
  • pancreatectomy
  • post-operative mortality

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Postoperative mortality following multi-modality therapy for pancreatic cancer : Analysis of the SEER-Medicare data. / Nayar, Preethy; Chandak, Aastha; Gupta, Niodita; Yu, Fang; Qiu, Fang; Ganti, Apar Kishor P; Are, Chandrakanth.

In: Journal of Surgical Oncology, Vol. 115, No. 2, 01.02.2017, p. 158-163.

Research output: Contribution to journalArticle

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abstract = "Background and Objectives: The objective of this study was to examine post-operative mortality for elderly pancreatic cancer patients treated with multi-modality therapy. Methods: Surveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy). Results: Among 4,105 patients who underwent pancreatectomy between 1991 and 2008, 1-year mortality (Odds Ratio [OR] = 0.71; P-value = 0.000; 95{\%} Confidence Interval [CI]: 0.60–0.85) and 6-month mortality (OR = 0.44; P-value = 0.000; 95{\%}CI: 0.35–0.53) following pancreatectomy were significantly lower in the group that underwent pancreatectomy with early adjuvant therapy. Late adjuvant therapy group also had lower 1 year (OR = 0.51; P-value = 0.000; 95{\%}CI: 0.43–0.61) and 6 months (OR = 0.14; P-value = 0.000; 95{\%}CI: 0.10–0.17) mortality, compared to surgery alone. Conclusions: Post-operative outcomes were better for patients treated with surgery with adjuvant therapy, with the late adjuvant therapy group having the best outcomes (lowest odds of 6 month and 1-year mortality following surgery). J. Surg. Oncol. 2017;115:158–163.",
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AU - Nayar, Preethy

AU - Chandak, Aastha

AU - Gupta, Niodita

AU - Yu, Fang

AU - Qiu, Fang

AU - Ganti, Apar Kishor P

AU - Are, Chandrakanth

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N2 - Background and Objectives: The objective of this study was to examine post-operative mortality for elderly pancreatic cancer patients treated with multi-modality therapy. Methods: Surveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy). Results: Among 4,105 patients who underwent pancreatectomy between 1991 and 2008, 1-year mortality (Odds Ratio [OR] = 0.71; P-value = 0.000; 95% Confidence Interval [CI]: 0.60–0.85) and 6-month mortality (OR = 0.44; P-value = 0.000; 95%CI: 0.35–0.53) following pancreatectomy were significantly lower in the group that underwent pancreatectomy with early adjuvant therapy. Late adjuvant therapy group also had lower 1 year (OR = 0.51; P-value = 0.000; 95%CI: 0.43–0.61) and 6 months (OR = 0.14; P-value = 0.000; 95%CI: 0.10–0.17) mortality, compared to surgery alone. Conclusions: Post-operative outcomes were better for patients treated with surgery with adjuvant therapy, with the late adjuvant therapy group having the best outcomes (lowest odds of 6 month and 1-year mortality following surgery). J. Surg. Oncol. 2017;115:158–163.

AB - Background and Objectives: The objective of this study was to examine post-operative mortality for elderly pancreatic cancer patients treated with multi-modality therapy. Methods: Surveillance Epidemiology and End Results (SEER) Medicare linked data were used to examine differences in mortality between patients who underwent pancreatectomy alone and those who had early (within 12 weeks) and late (after 12 weeks) adjuvant therapy (chemotherapy and/or radiotherapy). Results: Among 4,105 patients who underwent pancreatectomy between 1991 and 2008, 1-year mortality (Odds Ratio [OR] = 0.71; P-value = 0.000; 95% Confidence Interval [CI]: 0.60–0.85) and 6-month mortality (OR = 0.44; P-value = 0.000; 95%CI: 0.35–0.53) following pancreatectomy were significantly lower in the group that underwent pancreatectomy with early adjuvant therapy. Late adjuvant therapy group also had lower 1 year (OR = 0.51; P-value = 0.000; 95%CI: 0.43–0.61) and 6 months (OR = 0.14; P-value = 0.000; 95%CI: 0.10–0.17) mortality, compared to surgery alone. Conclusions: Post-operative outcomes were better for patients treated with surgery with adjuvant therapy, with the late adjuvant therapy group having the best outcomes (lowest odds of 6 month and 1-year mortality following surgery). J. Surg. Oncol. 2017;115:158–163.

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