Postnatal Nutrient Repartitioning due to Adaptive Developmental Programming

Robert J. Posont, Dustin T. Yates

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Fetal stress induces developmental adaptations that result in intrauterine growth restriction (IUGR) and low birthweight. These adaptations reappropriate nutrients to the most essential tissues, which benefits fetal survival. The same adaptations are detrimental to growth efficiency and carcass value in livestock, however, because muscle is disproportionally targeted. IUGR adipocytes, liver tissues, and pancreatic β-cells also exhibit functional adaptations. Identifying mechanisms underlying adaptive changes is fundamental to improving outcomes and value in low birthweight livestock. The article outlines studies that have begun to identify stress-induced fetal adaptations affecting growth, metabolism, and differential nutrient utilization in IUGR-born animals.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalVeterinary Clinics of North America - Food Animal Practice
Volume35
Issue number2
DOIs
Publication statusPublished - Jul 2019

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Keywords

  • Developmental origins of health and disease
  • Fetal adaptations
  • Fetal stress
  • Nutrient repartitioning
  • Thrifty phenotype

ASJC Scopus subject areas

  • Food Animals

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