Positive and negative selection on the mitochondrial genome

Colin D Meiklejohn, Kristi L. Montooth, David M. Rand

Research output: Contribution to journalShort survey

190 Citations (Scopus)

Abstract

Several recent studies have confirmed that mitochondrial DNA variation and evolution are not consistent with the neutral theory of molecular evolution and might be inappropriate for estimating effective population sizes. Evidence for the action of both positive and negative selection on mitochondrial genes has been put forward, and the complex genetics of mitochondrial DNA adds to the challenge of resolving this debate. The solution could lie in distinguishing genetic drift from 'genetic draft' and in dissecting the physiology of mitochondrial fitness.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalTrends in Genetics
Volume23
Issue number6
DOIs
StatePublished - Jun 1 2007

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Mitochondrial Genome
Mitochondrial DNA
Genetic Drift
Mitochondrial Genes
Molecular Evolution
Population Density

ASJC Scopus subject areas

  • Genetics

Cite this

Positive and negative selection on the mitochondrial genome. / Meiklejohn, Colin D; Montooth, Kristi L.; Rand, David M.

In: Trends in Genetics, Vol. 23, No. 6, 01.06.2007, p. 259-263.

Research output: Contribution to journalShort survey

Meiklejohn, Colin D ; Montooth, Kristi L. ; Rand, David M. / Positive and negative selection on the mitochondrial genome. In: Trends in Genetics. 2007 ; Vol. 23, No. 6. pp. 259-263.
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