Polypoid tumor of the esophagus

James Linder, Robert B. Stein, Victor L. Roggli, Robin T. Vollmer, Byron P. Croker, Raymond W. Postlethwait, John D. Shelburne

Research output: Contribution to journalArticle

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Abstract

Five cases of an uncommon esophageal tumor consisting of a mucosal squamous cell carcinoma that surrounds a polypoid mass of spindle cells were examined. The spindle cell component was composed of elongated cells with blunt nuclei, admixed with multinucleated giant cells. Reticulin fibers enveloped individual cells, and abundant collagen was present. Thirteen to 69 mitotic figures occurred per 10 high-power fields. Electron microscopy showed dilated cisternae of rough endoplasmic reticulum and peripheral intermediate filaments within the cytoplasm. Intermediate-type junctions (zonulae adherens) and subplasmalemmal linear densities connected some cells. No tonofibrillar bundles or desmosomes (maculae adherens) were present. Immunoperoxidase stains detected no keratin in the spindle cells. Alpha-1-antichymotrypsin and alpha-1-antitrypsin were in the spindle cells in five of five and three of five cases, respectively. The absence of desmosomes, tonofibrillar bundles, and keratin and the presence of alpha-1-antitrypsin and alpha-1-anti-chymotrypsin favor fibrohistiocytic differentiation of the spindle cell component.

Original languageEnglish (US)
Pages (from-to)692-700
Number of pages9
JournalHuman Pathology
Volume18
Issue number7
DOIs
StatePublished - Jul 1987

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Esophagus
Neoplasms
Desmosomes
alpha 1-Antitrypsin
Cellular Structures
Keratins
alpha 1-Antichymotrypsin
Reticulin
Adherens Junctions
Intermediate Filaments
Rough Endoplasmic Reticulum
Chymotrypsin
Giant Cells
Squamous Cell Carcinoma
Electron Microscopy
Cytoplasm
Coloring Agents
Collagen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Linder, J., Stein, R. B., Roggli, V. L., Vollmer, R. T., Croker, B. P., Postlethwait, R. W., & Shelburne, J. D. (1987). Polypoid tumor of the esophagus. Human Pathology, 18(7), 692-700. https://doi.org/10.1016/S0046-8177(87)80240-X

Polypoid tumor of the esophagus. / Linder, James; Stein, Robert B.; Roggli, Victor L.; Vollmer, Robin T.; Croker, Byron P.; Postlethwait, Raymond W.; Shelburne, John D.

In: Human Pathology, Vol. 18, No. 7, 07.1987, p. 692-700.

Research output: Contribution to journalArticle

Linder, J, Stein, RB, Roggli, VL, Vollmer, RT, Croker, BP, Postlethwait, RW & Shelburne, JD 1987, 'Polypoid tumor of the esophagus', Human Pathology, vol. 18, no. 7, pp. 692-700. https://doi.org/10.1016/S0046-8177(87)80240-X
Linder J, Stein RB, Roggli VL, Vollmer RT, Croker BP, Postlethwait RW et al. Polypoid tumor of the esophagus. Human Pathology. 1987 Jul;18(7):692-700. https://doi.org/10.1016/S0046-8177(87)80240-X
Linder, James ; Stein, Robert B. ; Roggli, Victor L. ; Vollmer, Robin T. ; Croker, Byron P. ; Postlethwait, Raymond W. ; Shelburne, John D. / Polypoid tumor of the esophagus. In: Human Pathology. 1987 ; Vol. 18, No. 7. pp. 692-700.
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