Polyplex gene delivery modulated by redox potential gradients

Devika Soundara Manickam, David Oupický

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Polyplexes sensitive to redox potential gradients represent a promising class of vectors for delivery of nucleic acids. This review focuses on the recent advances in the development of these vectors. The biological rationale for the design of redox-sensitive polyplexes is discussed together with the basic synthetic approaches for introducing reducible disulfide bonds into the structure of the polyplexes. The biological properties of the redox-sensitive polyplexes of plasmid DNA, mRNA, antisense oligonucleotides and siRNA are reviewed with emphasis on in vitro cellular delivery, cytotoxicity and in vivo activity. Overall, redox-sensitive polyplexes represent a promising platform for further development as vectors for delivery of a wide variety of therapeutic nucleic acids.

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalJournal of Drug Targeting
Volume14
Issue number8
DOIs
StatePublished - Sep 1 2006

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Keywords

  • Gene delivery
  • Glutathione
  • Polycations
  • Polyplexes

ASJC Scopus subject areas

  • Pharmaceutical Science

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