Polyplex gene delivery modulated by redox potential gradients

Devika Soundara Manickam, David Oupický

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Polyplexes sensitive to redox potential gradients represent a promising class of vectors for delivery of nucleic acids. This review focuses on the recent advances in the development of these vectors. The biological rationale for the design of redox-sensitive polyplexes is discussed together with the basic synthetic approaches for introducing reducible disulfide bonds into the structure of the polyplexes. The biological properties of the redox-sensitive polyplexes of plasmid DNA, mRNA, antisense oligonucleotides and siRNA are reviewed with emphasis on in vitro cellular delivery, cytotoxicity and in vivo activity. Overall, redox-sensitive polyplexes represent a promising platform for further development as vectors for delivery of a wide variety of therapeutic nucleic acids.

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalJournal of Drug Targeting
Volume14
Issue number8
DOIs
StatePublished - Sep 1 2006

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Oxidation-Reduction
Nucleic Acids
Genes
Antisense Oligonucleotides
Disulfides
Small Interfering RNA
Plasmids
Messenger RNA
DNA
Therapeutics

Keywords

  • Gene delivery
  • Glutathione
  • Polycations
  • Polyplexes

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Polyplex gene delivery modulated by redox potential gradients. / Soundara Manickam, Devika; Oupický, David.

In: Journal of Drug Targeting, Vol. 14, No. 8, 01.09.2006, p. 519-526.

Research output: Contribution to journalReview article

Soundara Manickam, Devika ; Oupický, David. / Polyplex gene delivery modulated by redox potential gradients. In: Journal of Drug Targeting. 2006 ; Vol. 14, No. 8. pp. 519-526.
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