Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk

Rick J Jansen, Dennis P. Robinson, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Xianglin Tan, Julie M. Cunningham, Ying Li, David N. Rider, Ann L. Oberg, Kari G. Rabe, Kristin E. Anderson, Rashmi Sinha, Gloria M. Petersen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: A source of variation for inconsistent dietary-pancreatic cancer associations may be individuals carrying constitutional metabolism/antioxidant gene variants that differentially benefit compared to homozygous individuals. Seventy-six tag single-nucleotide polymorphisms were genotyped in 13 candidate genes to test differential associations with pancreatic adenocarcinoma. Methods: A clinic-based case-control design was used to rapidly ascertain 251 cases and 970 frequency matched controls who provided blood samples and completed a 144-item food frequency questionnaire. Single-nucleotide polymorphisms were evaluated using a dominant genetic model and dietary categories split on controls' median intake. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusted for potential confounders. Results: Significant increased associations (Bonferroni corrected P ≤ 0.0007) were observed for carriers of greater than or equal to 1 minor allele for rs3816257 (glucosidase, α; acid [GAA]) and lower intake of deep-yellow vegetables (1.90 [1.28-2.83]); and carriers of no minor allele for rs12807961 (catalase [CAT]) and high total grains intake (2.48 [1.50-4.09]), whereas those with greater than or equal to 1 minor allele had a decreasing slope (across grains). The reference group was no minor alleles with low dietary intake. Conclusions: Interindividual variation in metabolism/antioxidant genes could interact with dietary intake to influence pancreatic cancer risk.

Original languageEnglish (US)
Pages (from-to)1043-1053
Number of pages11
JournalPancreas
Volume42
Issue number7
DOIs
StatePublished - Oct 1 2013

Fingerprint

Pancreatic Neoplasms
Antioxidants
Alleles
Genes
Single Nucleotide Polymorphism
Glucosidases
Genetic Models
Vegetables
Catalase
Adenocarcinoma
Logistic Models
Odds Ratio
Confidence Intervals
Food
Acids

Keywords

  • case-control
  • dietary risk factors
  • genetic risk factors
  • interaction
  • pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Jansen, R. J., Robinson, D. P., Stolzenberg-Solomon, R. Z., Bamlet, W. R., Tan, X., Cunningham, J. M., ... Petersen, G. M. (2013). Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. Pancreas, 42(7), 1043-1053. https://doi.org/10.1097/MPA.0b013e3182968e00

Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. / Jansen, Rick J; Robinson, Dennis P.; Stolzenberg-Solomon, Rachael Z.; Bamlet, William R.; Tan, Xianglin; Cunningham, Julie M.; Li, Ying; Rider, David N.; Oberg, Ann L.; Rabe, Kari G.; Anderson, Kristin E.; Sinha, Rashmi; Petersen, Gloria M.

In: Pancreas, Vol. 42, No. 7, 01.10.2013, p. 1043-1053.

Research output: Contribution to journalArticle

Jansen, RJ, Robinson, DP, Stolzenberg-Solomon, RZ, Bamlet, WR, Tan, X, Cunningham, JM, Li, Y, Rider, DN, Oberg, AL, Rabe, KG, Anderson, KE, Sinha, R & Petersen, GM 2013, 'Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk', Pancreas, vol. 42, no. 7, pp. 1043-1053. https://doi.org/10.1097/MPA.0b013e3182968e00
Jansen, Rick J ; Robinson, Dennis P. ; Stolzenberg-Solomon, Rachael Z. ; Bamlet, William R. ; Tan, Xianglin ; Cunningham, Julie M. ; Li, Ying ; Rider, David N. ; Oberg, Ann L. ; Rabe, Kari G. ; Anderson, Kristin E. ; Sinha, Rashmi ; Petersen, Gloria M. / Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. In: Pancreas. 2013 ; Vol. 42, No. 7. pp. 1043-1053.
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abstract = "Objectives: A source of variation for inconsistent dietary-pancreatic cancer associations may be individuals carrying constitutional metabolism/antioxidant gene variants that differentially benefit compared to homozygous individuals. Seventy-six tag single-nucleotide polymorphisms were genotyped in 13 candidate genes to test differential associations with pancreatic adenocarcinoma. Methods: A clinic-based case-control design was used to rapidly ascertain 251 cases and 970 frequency matched controls who provided blood samples and completed a 144-item food frequency questionnaire. Single-nucleotide polymorphisms were evaluated using a dominant genetic model and dietary categories split on controls' median intake. Logistic regression was used to calculate odds ratios and 95{\%} confidence intervals, adjusted for potential confounders. Results: Significant increased associations (Bonferroni corrected P ≤ 0.0007) were observed for carriers of greater than or equal to 1 minor allele for rs3816257 (glucosidase, α; acid [GAA]) and lower intake of deep-yellow vegetables (1.90 [1.28-2.83]); and carriers of no minor allele for rs12807961 (catalase [CAT]) and high total grains intake (2.48 [1.50-4.09]), whereas those with greater than or equal to 1 minor allele had a decreasing slope (across grains). The reference group was no minor alleles with low dietary intake. Conclusions: Interindividual variation in metabolism/antioxidant genes could interact with dietary intake to influence pancreatic cancer risk.",
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AU - Tan, Xianglin

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AU - Oberg, Ann L.

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