Polymeric nanogel formulations of nucleoside analogs

Serguei V. Vinogradov

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Nanogels are colloidal microgel carriers that have been recently introduced as a prospective drug delivery system for nucleotide therapeutics. The crosslinked protonated polymer network of nanogels binds oppositely charged drug molecules, encapsulating them into submicron particles with a core-shell structure. The nanogel network also provides a suitable template for chemical engineering, surface modification and vectorisation. This review reveals recent attempts to develop novel drug formulations of nanogels with antiviral and antiproliferative nucleoside analogs in the active form of 5′-triphosphates, discusses structural approaches to the optimisation of nanogel properties, and discusses the development of targeted nanogel drug formulations for systemic administration. Notably, nanogels can improve the CNS penetration of nucleoside analogs that are otherwise restricted from passing across the blood-brain barrier. The latest findings reviewed here demonstrate an efficient intracellular release of nucleoside analogs, encouraging further applications of nanogel carriers for targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)5-17
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2007

Fingerprint

Nucleosides
Drug Compounding
Chemical Engineering
Drug Carriers
NanoGel
Drug Delivery Systems
Blood-Brain Barrier
Antiviral Agents
Polymers
Nucleotides
Pharmaceutical Preparations

Keywords

  • Accumulation enhancement
  • Drug delivery
  • Nucleoside 5′-triphosphates
  • Polymeric microgels
  • Structural modification
  • Triggered drug release
  • Vectorisation

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Polymeric nanogel formulations of nucleoside analogs. / Vinogradov, Serguei V.

In: Expert Opinion on Drug Delivery, Vol. 4, No. 1, 01.01.2007, p. 5-17.

Research output: Contribution to journalReview article

Vinogradov, Serguei V. / Polymeric nanogel formulations of nucleoside analogs. In: Expert Opinion on Drug Delivery. 2007 ; Vol. 4, No. 1. pp. 5-17.
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