Abstract
Bacterial biofilm formation on implant surfaces is a frequent reason for the failure of many biomedical devices. Polymer brushes, thin nanolayers constituted of densely grafted macromolecules, are promising candidates to use in many biomedical applications to control attachment of bacteria to a surface. In this work five different polymer brushes were synthesized and tested with respect to their ability to regulate Staphylococcus aureus adhesion. Namely, two mixed brushes [consisting of poly(ethylene glycol) and a positively charged polymers, poly(2-vynil pyridine) or quartenized poly(2-vynil pyridine)] are investigated along with one-component brushes of the respective polymers. Bacterial adhesion was regulated over two orders of magnitude via altering the polymer brush composition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 680-684 |
| Number of pages | 5 |
| Journal | Materials Science and Engineering C |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 30 2009 |
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Keywords
- PEG
- PGMA
- bacteria adhesion
- bacteria-centered infection
- biofilm
- polymer brush
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
Polymer brushes as active nanolayers for tunable bacteria adhesion. / Zdyrko, Bogdan; Klep, Viktor; Li, Xiaowei; Kang, Qian; Minko, Sergiy; Wen, Xuejun; Luzinov, Igor.
In: Materials Science and Engineering C, Vol. 29, No. 3, 30.04.2009, p. 680-684.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymer brushes as active nanolayers for tunable bacteria adhesion
AU - Zdyrko, Bogdan
AU - Klep, Viktor
AU - Li, Xiaowei
AU - Kang, Qian
AU - Minko, Sergiy
AU - Wen, Xuejun
AU - Luzinov, Igor
PY - 2009/4/30
Y1 - 2009/4/30
N2 - Bacterial biofilm formation on implant surfaces is a frequent reason for the failure of many biomedical devices. Polymer brushes, thin nanolayers constituted of densely grafted macromolecules, are promising candidates to use in many biomedical applications to control attachment of bacteria to a surface. In this work five different polymer brushes were synthesized and tested with respect to their ability to regulate Staphylococcus aureus adhesion. Namely, two mixed brushes [consisting of poly(ethylene glycol) and a positively charged polymers, poly(2-vynil pyridine) or quartenized poly(2-vynil pyridine)] are investigated along with one-component brushes of the respective polymers. Bacterial adhesion was regulated over two orders of magnitude via altering the polymer brush composition.
AB - Bacterial biofilm formation on implant surfaces is a frequent reason for the failure of many biomedical devices. Polymer brushes, thin nanolayers constituted of densely grafted macromolecules, are promising candidates to use in many biomedical applications to control attachment of bacteria to a surface. In this work five different polymer brushes were synthesized and tested with respect to their ability to regulate Staphylococcus aureus adhesion. Namely, two mixed brushes [consisting of poly(ethylene glycol) and a positively charged polymers, poly(2-vynil pyridine) or quartenized poly(2-vynil pyridine)] are investigated along with one-component brushes of the respective polymers. Bacterial adhesion was regulated over two orders of magnitude via altering the polymer brush composition.
KW - PEG
KW - PGMA
KW - bacteria adhesion
KW - bacteria-centered infection
KW - biofilm
KW - polymer brush
UR - http://www.scopus.com/inward/record.url?scp=64749098674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64749098674&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2008.12.017
DO - 10.1016/j.msec.2008.12.017
M3 - Article
AN - SCOPUS:64749098674
VL - 29
SP - 680
EP - 684
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
IS - 3
ER -