Polylactide-polyglycolide antibiotic implants

Kevin Lloyd Garvin, Connie Feschuk

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Surgeons continually struggle to reduce orthopaedic infections, but no current treatment offers minimum side effects with maximum effectiveness. Antibiotics mixed in plaster of paris have been successful in treating large bony defects in patients with chronic osteomyelitis, and have the advantage of being well tolerated and absorbed by the body. Antibiotics impregnated in polymethylmethacrylate (PMMA) have offered local antibiotic delivery with some success. However, the effect of the antibiotic on the bone cement, the inconsistent elution of the antibiotic, and the need to remove the PMMA implant drives the need for a better system of antibiotic delivery. Polymers or copolymers of antibiotic-impregnated polylactic acid, polyglycolic acid or polyparadioxanone may provide an absorbable system for localized antibiotic delivery. Similar biodegradable systems used to treat small bone fractures have been successful with minimal side effects. In vitro studies have shown promising results of antibiotic elution from bioabsorbable microspheres and beads. Animal in vivo tests have shown that antibiotic impregnated polymers can successfully treat induced osteomyelitis in rabbits and dogs. These studies have provided consistent reproducible results, and now it is time to plan human trials to assess the efficacy of antibiotic microspheres implanted in infected bone and to plan in vivo and in vitro animal testing to investigate the feasibility of antibiotic-polymer-coated components.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalClinical Orthopaedics and Related Research
Issue number437
DOIs
StatePublished - Aug 2005

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Polyglycolic Acid
Anti-Bacterial Agents
Polymers
Polymethyl Methacrylate
Osteomyelitis
Microspheres
poly(lactide)
Calcium Sulfate
Bone Cements
Bone Fractures
Orthopedics

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Polylactide-polyglycolide antibiotic implants. / Garvin, Kevin Lloyd; Feschuk, Connie.

In: Clinical Orthopaedics and Related Research, No. 437, 08.2005, p. 105-110.

Research output: Contribution to journalArticle

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