Polyamines and platelet aggregation

Owen Rennert, Bruce Buehler, Thomas Miale, Daniel Lawson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalLife Sciences
Volume19
Issue number2
DOIs
StatePublished - Jul 15 1976

Fingerprint

Ristocetin
Polycythemia Vera
Platelet-Rich Plasma
Spermidine
Spermine
Polyamines
Platelets
Platelet Aggregation
Psoriasis
Cystic Fibrosis
Adenosine Diphosphate
Cations
Leukemia
Blood Platelets
Agglomeration
Blood
Plasmas
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Rennert, O., Buehler, B., Miale, T., & Lawson, D. (1976). Polyamines and platelet aggregation. Life Sciences, 19(2), 257-264. https://doi.org/10.1016/0024-3205(76)90398-2

Polyamines and platelet aggregation. / Rennert, Owen; Buehler, Bruce; Miale, Thomas; Lawson, Daniel.

In: Life Sciences, Vol. 19, No. 2, 15.07.1976, p. 257-264.

Research output: Contribution to journalArticle

Rennert, O, Buehler, B, Miale, T & Lawson, D 1976, 'Polyamines and platelet aggregation', Life Sciences, vol. 19, no. 2, pp. 257-264. https://doi.org/10.1016/0024-3205(76)90398-2
Rennert O, Buehler B, Miale T, Lawson D. Polyamines and platelet aggregation. Life Sciences. 1976 Jul 15;19(2):257-264. https://doi.org/10.1016/0024-3205(76)90398-2
Rennert, Owen ; Buehler, Bruce ; Miale, Thomas ; Lawson, Daniel. / Polyamines and platelet aggregation. In: Life Sciences. 1976 ; Vol. 19, No. 2. pp. 257-264.
@article{22b51f160ac34a31bd926cbda30bdfdd,
title = "Polyamines and platelet aggregation",
abstract = "High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.",
author = "Owen Rennert and Bruce Buehler and Thomas Miale and Daniel Lawson",
year = "1976",
month = "7",
day = "15",
doi = "10.1016/0024-3205(76)90398-2",
language = "English (US)",
volume = "19",
pages = "257--264",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Polyamines and platelet aggregation

AU - Rennert, Owen

AU - Buehler, Bruce

AU - Miale, Thomas

AU - Lawson, Daniel

PY - 1976/7/15

Y1 - 1976/7/15

N2 - High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

AB - High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

UR - http://www.scopus.com/inward/record.url?scp=0017082432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017082432&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(76)90398-2

DO - 10.1016/0024-3205(76)90398-2

M3 - Article

C2 - 957869

AN - SCOPUS:0017082432

VL - 19

SP - 257

EP - 264

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 2

ER -