Poly(2-oxazoline) block copolymer based formulations of taxanes: Effect of copolymer and drug structure, concentration, and environmental factors

Youngee Seo, Anita Schulz, Yingchao Han, Zhijian He, Herdis Bludau, Xiaomeng Wan, Jing Tong, Tatiana K Bronich, Marina Sokolsky, Robert Luxenhofer, Rainer Jordan, Alexander V. Kabanov

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Many current nanoformulations of taxanes are hampered by low drug-loading capacity and unfavorable physicochemical characteristics such as large particles size (>100nm) and/or low size uniformity. We have previously reported on taxane nanoformulations, based on poly(2-oxazoline) polymeric micelles that display an extremely high taxane loading capacity (>40%w/w) and particle size below 50nm. Previous work was based on a triblock copolymer having poly(2-butyl-2-oxazoline) as the hydrophobic block and poly(2-methyl-2-oxazoline) as the hydrophilic blocks. This paper explores the effects of various formulation parameters such as (i) the drug and polymer structure; (ii) the drug and polymer concentration; and (iii) the composition of aqueous medium on the solubilization behavior and physicochemical properties of the resulting formulations. In addition, in vitro anticancer activity is reported. Despite numerous variations of the hydrophobicity, polarity or addition of aromatic residues in the hydrophobic core, the triblock copolymer with the poly(2-butyl-2-oxazoline) block remains the polymer with the highest drug-loading capacity. Notably, the formulation was easily scalable with uncompromised encapsulation efficacy, loading capacity, and physicochemical properties. The taxane formulations were stable upon storage (water, saline, and dextrose solution) for 1-2weeks and could be lyophilized and re-dispersed without compromising the formulation properties. Furthermore, the micelles remained stable upon dilution. The drug-loaded poly(2-oxazoline) micelles showed high toxicity against several cancer cell lines. Taken together, these results underscore the potential of poly(2-oxazoline) micelles as formulation excipient for taxanes and possibly other hydrophobic drugs.

Original languageEnglish (US)
Pages (from-to)837-850
Number of pages14
JournalPolymers for Advanced Technologies
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Taxoids
Micelles
Block copolymers
Copolymers
Pharmaceutical Preparations
Polymers
Particle size
Dextrose
Saline water
Hydrophobicity
Encapsulation
Dilution
Toxicity
Excipients
Cells
poly(2-oxazoline)
Chemical analysis
Glucose
taxane

Keywords

  • Block copolymer micelles
  • Docetaxel
  • Drug delivery
  • Nanomedicine
  • Paclitaxel
  • Poly(2-oxazoline)

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Poly(2-oxazoline) block copolymer based formulations of taxanes : Effect of copolymer and drug structure, concentration, and environmental factors. / Seo, Youngee; Schulz, Anita; Han, Yingchao; He, Zhijian; Bludau, Herdis; Wan, Xiaomeng; Tong, Jing; Bronich, Tatiana K; Sokolsky, Marina; Luxenhofer, Robert; Jordan, Rainer; Kabanov, Alexander V.

In: Polymers for Advanced Technologies, Vol. 26, No. 7, 01.07.2015, p. 837-850.

Research output: Contribution to journalArticle

Seo, Y, Schulz, A, Han, Y, He, Z, Bludau, H, Wan, X, Tong, J, Bronich, TK, Sokolsky, M, Luxenhofer, R, Jordan, R & Kabanov, AV 2015, 'Poly(2-oxazoline) block copolymer based formulations of taxanes: Effect of copolymer and drug structure, concentration, and environmental factors', Polymers for Advanced Technologies, vol. 26, no. 7, pp. 837-850. https://doi.org/10.1002/pat.3556
Seo, Youngee ; Schulz, Anita ; Han, Yingchao ; He, Zhijian ; Bludau, Herdis ; Wan, Xiaomeng ; Tong, Jing ; Bronich, Tatiana K ; Sokolsky, Marina ; Luxenhofer, Robert ; Jordan, Rainer ; Kabanov, Alexander V. / Poly(2-oxazoline) block copolymer based formulations of taxanes : Effect of copolymer and drug structure, concentration, and environmental factors. In: Polymers for Advanced Technologies. 2015 ; Vol. 26, No. 7. pp. 837-850.
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