Polarity in filamentous fungi: Moving beyond the yeast paradigm

Steven D. Harris, Michelle Momany

Research output: Contribution to journalReview article

152 Citations (Scopus)

Abstract

Filamentous fungi grow by the polar extension of hyphae. This polar growth requires the specification of sites of germ tube or branch emergence, followed by the recruitment of the morphogenetic machinery to those sites for localized cell wall deposition. Researchers attempting to understand hyphal morphogenesis have relied upon the powerful paradigm of bud emergence in the yeast Saccharomyces cerevisiae. The yeast paradigm has provided a useful framework, however several features of hyphal morphogenesis, such as the ability to maintain multiple axes of polarity and an extremely rapid extension rate, cannot be explained by simple extrapolation from yeast models. We discuss recent polarity research from filamentous fungi focusing on the position of germ tube emergence, the relaying of positional information via RhoGTPase modules, and the recruitment of morphogenetic machinery components including cytoskeleton, polarisome and ARP2/3 complexes, and the vesicle trafficking system.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalFungal Genetics and Biology
Volume41
Issue number4
DOIs
StatePublished - Apr 1 2004

Fingerprint

Fungi
Yeasts
Morphogenesis
Hyphae
Cytoskeleton
Cell Wall
Saccharomyces cerevisiae
Research Personnel
Growth
Research

Keywords

  • Branching
  • Germ tube emergence
  • Morphogenesis
  • Polar growth
  • Polarity

ASJC Scopus subject areas

  • Microbiology
  • Genetics

Cite this

Polarity in filamentous fungi : Moving beyond the yeast paradigm. / Harris, Steven D.; Momany, Michelle.

In: Fungal Genetics and Biology, Vol. 41, No. 4, 01.04.2004, p. 391-400.

Research output: Contribution to journalReview article

Harris, Steven D. ; Momany, Michelle. / Polarity in filamentous fungi : Moving beyond the yeast paradigm. In: Fungal Genetics and Biology. 2004 ; Vol. 41, No. 4. pp. 391-400.
@article{5a0cb0f310b14e468a0bbcf30e5953bf,
title = "Polarity in filamentous fungi: Moving beyond the yeast paradigm",
abstract = "Filamentous fungi grow by the polar extension of hyphae. This polar growth requires the specification of sites of germ tube or branch emergence, followed by the recruitment of the morphogenetic machinery to those sites for localized cell wall deposition. Researchers attempting to understand hyphal morphogenesis have relied upon the powerful paradigm of bud emergence in the yeast Saccharomyces cerevisiae. The yeast paradigm has provided a useful framework, however several features of hyphal morphogenesis, such as the ability to maintain multiple axes of polarity and an extremely rapid extension rate, cannot be explained by simple extrapolation from yeast models. We discuss recent polarity research from filamentous fungi focusing on the position of germ tube emergence, the relaying of positional information via RhoGTPase modules, and the recruitment of morphogenetic machinery components including cytoskeleton, polarisome and ARP2/3 complexes, and the vesicle trafficking system.",
keywords = "Branching, Germ tube emergence, Morphogenesis, Polar growth, Polarity",
author = "Harris, {Steven D.} and Michelle Momany",
year = "2004",
month = "4",
day = "1",
doi = "10.1016/j.fgb.2003.11.007",
language = "English (US)",
volume = "41",
pages = "391--400",
journal = "Fungal Genetics and Biology",
issn = "1087-1845",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Polarity in filamentous fungi

T2 - Moving beyond the yeast paradigm

AU - Harris, Steven D.

AU - Momany, Michelle

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Filamentous fungi grow by the polar extension of hyphae. This polar growth requires the specification of sites of germ tube or branch emergence, followed by the recruitment of the morphogenetic machinery to those sites for localized cell wall deposition. Researchers attempting to understand hyphal morphogenesis have relied upon the powerful paradigm of bud emergence in the yeast Saccharomyces cerevisiae. The yeast paradigm has provided a useful framework, however several features of hyphal morphogenesis, such as the ability to maintain multiple axes of polarity and an extremely rapid extension rate, cannot be explained by simple extrapolation from yeast models. We discuss recent polarity research from filamentous fungi focusing on the position of germ tube emergence, the relaying of positional information via RhoGTPase modules, and the recruitment of morphogenetic machinery components including cytoskeleton, polarisome and ARP2/3 complexes, and the vesicle trafficking system.

AB - Filamentous fungi grow by the polar extension of hyphae. This polar growth requires the specification of sites of germ tube or branch emergence, followed by the recruitment of the morphogenetic machinery to those sites for localized cell wall deposition. Researchers attempting to understand hyphal morphogenesis have relied upon the powerful paradigm of bud emergence in the yeast Saccharomyces cerevisiae. The yeast paradigm has provided a useful framework, however several features of hyphal morphogenesis, such as the ability to maintain multiple axes of polarity and an extremely rapid extension rate, cannot be explained by simple extrapolation from yeast models. We discuss recent polarity research from filamentous fungi focusing on the position of germ tube emergence, the relaying of positional information via RhoGTPase modules, and the recruitment of morphogenetic machinery components including cytoskeleton, polarisome and ARP2/3 complexes, and the vesicle trafficking system.

KW - Branching

KW - Germ tube emergence

KW - Morphogenesis

KW - Polar growth

KW - Polarity

UR - http://www.scopus.com/inward/record.url?scp=1442309302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1442309302&partnerID=8YFLogxK

U2 - 10.1016/j.fgb.2003.11.007

DO - 10.1016/j.fgb.2003.11.007

M3 - Review article

C2 - 14998522

AN - SCOPUS:1442309302

VL - 41

SP - 391

EP - 400

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

SN - 1087-1845

IS - 4

ER -