Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma

John T. Sandlund, William M. Crist, Minnie Abromowitch, Diane Fairclough, Costan W. Berard, Mary Rafferty, Ching Hon Pui

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The clinical significance of pleural effusion was assessed in 24 children with unresectable abdominal small non-cleaved cell lymphoma (St. Jude Stage III). Patients were consecutively enrolled and treated on a regimen including high dose fractionated cyclophosphamide and co-ordinated high dose methotrexate and cytarabine. The overall results were excellent, with 20 of 24 patients alive and event-free at a median follow-up of 4 years. Only one of the patients who lacked pleural effusion has relapsed (testicular), even though many had massive disease. In contrast, three of seven patients with pleural effusion have failed treatment (p=0.02) and subsequently died. Two measures of tumor burden, serum lactic dehydrogenase and, in a subset of patients, interleukin-2-receptor levels, were significantly higher in patients with pleural effusion (p=0.002 and p=0.05, respectively). These findings suggest that unresectable abdominal small non-cleaved cell lymphoma associated with pleural effusion should be up-staged and that these patients should receive more intensive chemotherapy.

Original languageEnglish (US)
Pages (from-to)71-74
Number of pages4
JournalLeukemia
Volume5
Issue number1
StatePublished - Jan 1 1991

Fingerprint

Pleural Effusion
Non-Hodgkin's Lymphoma
Interleukin-2 Receptors
Cytarabine
Tumor Burden
Methotrexate
Cyclophosphamide
Oxidoreductases
Milk
Drug Therapy
Serum

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Sandlund, J. T., Crist, W. M., Abromowitch, M., Fairclough, D., Berard, C. W., Rafferty, M., & Pui, C. H. (1991). Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma. Leukemia, 5(1), 71-74.

Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma. / Sandlund, John T.; Crist, William M.; Abromowitch, Minnie; Fairclough, Diane; Berard, Costan W.; Rafferty, Mary; Pui, Ching Hon.

In: Leukemia, Vol. 5, No. 1, 01.01.1991, p. 71-74.

Research output: Contribution to journalArticle

Sandlund, JT, Crist, WM, Abromowitch, M, Fairclough, D, Berard, CW, Rafferty, M & Pui, CH 1991, 'Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma', Leukemia, vol. 5, no. 1, pp. 71-74.
Sandlund JT, Crist WM, Abromowitch M, Fairclough D, Berard CW, Rafferty M et al. Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma. Leukemia. 1991 Jan 1;5(1):71-74.
Sandlund, John T. ; Crist, William M. ; Abromowitch, Minnie ; Fairclough, Diane ; Berard, Costan W. ; Rafferty, Mary ; Pui, Ching Hon. / Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma. In: Leukemia. 1991 ; Vol. 5, No. 1. pp. 71-74.
@article{8a9f2d4e98534beab989c1a04b5ec3a0,
title = "Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma",
abstract = "The clinical significance of pleural effusion was assessed in 24 children with unresectable abdominal small non-cleaved cell lymphoma (St. Jude Stage III). Patients were consecutively enrolled and treated on a regimen including high dose fractionated cyclophosphamide and co-ordinated high dose methotrexate and cytarabine. The overall results were excellent, with 20 of 24 patients alive and event-free at a median follow-up of 4 years. Only one of the patients who lacked pleural effusion has relapsed (testicular), even though many had massive disease. In contrast, three of seven patients with pleural effusion have failed treatment (p=0.02) and subsequently died. Two measures of tumor burden, serum lactic dehydrogenase and, in a subset of patients, interleukin-2-receptor levels, were significantly higher in patients with pleural effusion (p=0.002 and p=0.05, respectively). These findings suggest that unresectable abdominal small non-cleaved cell lymphoma associated with pleural effusion should be up-staged and that these patients should receive more intensive chemotherapy.",
author = "Sandlund, {John T.} and Crist, {William M.} and Minnie Abromowitch and Diane Fairclough and Berard, {Costan W.} and Mary Rafferty and Pui, {Ching Hon}",
year = "1991",
month = "1",
day = "1",
language = "English (US)",
volume = "5",
pages = "71--74",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Pleural effusion is associated with a poor treatment outcome in stage III small non-cleaved cell lymphoma

AU - Sandlund, John T.

AU - Crist, William M.

AU - Abromowitch, Minnie

AU - Fairclough, Diane

AU - Berard, Costan W.

AU - Rafferty, Mary

AU - Pui, Ching Hon

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The clinical significance of pleural effusion was assessed in 24 children with unresectable abdominal small non-cleaved cell lymphoma (St. Jude Stage III). Patients were consecutively enrolled and treated on a regimen including high dose fractionated cyclophosphamide and co-ordinated high dose methotrexate and cytarabine. The overall results were excellent, with 20 of 24 patients alive and event-free at a median follow-up of 4 years. Only one of the patients who lacked pleural effusion has relapsed (testicular), even though many had massive disease. In contrast, three of seven patients with pleural effusion have failed treatment (p=0.02) and subsequently died. Two measures of tumor burden, serum lactic dehydrogenase and, in a subset of patients, interleukin-2-receptor levels, were significantly higher in patients with pleural effusion (p=0.002 and p=0.05, respectively). These findings suggest that unresectable abdominal small non-cleaved cell lymphoma associated with pleural effusion should be up-staged and that these patients should receive more intensive chemotherapy.

AB - The clinical significance of pleural effusion was assessed in 24 children with unresectable abdominal small non-cleaved cell lymphoma (St. Jude Stage III). Patients were consecutively enrolled and treated on a regimen including high dose fractionated cyclophosphamide and co-ordinated high dose methotrexate and cytarabine. The overall results were excellent, with 20 of 24 patients alive and event-free at a median follow-up of 4 years. Only one of the patients who lacked pleural effusion has relapsed (testicular), even though many had massive disease. In contrast, three of seven patients with pleural effusion have failed treatment (p=0.02) and subsequently died. Two measures of tumor burden, serum lactic dehydrogenase and, in a subset of patients, interleukin-2-receptor levels, were significantly higher in patients with pleural effusion (p=0.002 and p=0.05, respectively). These findings suggest that unresectable abdominal small non-cleaved cell lymphoma associated with pleural effusion should be up-staged and that these patients should receive more intensive chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0025891101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025891101&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 71

EP - 74

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 1

ER -