Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat

G. D. Phillips, Anna Marika Stone, R. A. Whitehead, D. R. Knighton

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The object of this study was to determine the effect of PDWHF on wound healing angiogenesis. Sponges saturated with PDWHF were implanted in rats. Six hours to 14 days post-implantation, vascular corrosion casts were prepared and examined by SEM. Leukocyte margination and angiogenesis was accelerated by 24-48 hours. Vessel number was also greater than in the controls. Another series of PDWHF treated sponges were implanted. Fourteen days later the vasculature was perfused with Evans blue. Sponges were homogenized, and absorbance of the supernatants was determined. Absorbances of PDWHF supernatants was 2X greater than controls. PDWHF enhanced wound healing angiogenesis in the rat.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalIn Vivo
Volume8
Issue number2
StatePublished - Jan 1 1994

Fingerprint

Platelets
Wound Healing
Rats
Blood Platelets
Porifera
Evans Blue
Corrosion
Blood Vessels
Scanning electron microscopy
Leukocytes

Keywords

  • angiogenesis
  • endothelial cells
  • scanning electron microscopy
  • vascular corrosion casts
  • wound healing

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Phillips, G. D., Stone, A. M., Whitehead, R. A., & Knighton, D. R. (1994). Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat. In Vivo, 8(2), 167-172.

Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat. / Phillips, G. D.; Stone, Anna Marika; Whitehead, R. A.; Knighton, D. R.

In: In Vivo, Vol. 8, No. 2, 01.01.1994, p. 167-172.

Research output: Contribution to journalArticle

Phillips, GD, Stone, AM, Whitehead, RA & Knighton, DR 1994, 'Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat', In Vivo, vol. 8, no. 2, pp. 167-172.
Phillips GD, Stone AM, Whitehead RA, Knighton DR. Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat. In Vivo. 1994 Jan 1;8(2):167-172.
Phillips, G. D. ; Stone, Anna Marika ; Whitehead, R. A. ; Knighton, D. R. / Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat. In: In Vivo. 1994 ; Vol. 8, No. 2. pp. 167-172.
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