Plasticity of hippocampal circuitry in Alzheimer's disease

James W. Geddes, Daniel T. Monaghan, Carl W. Cotman, Ira T. Lott, Ronald C. Kim, Helena Chang Chui

Research output: Contribution to journalArticle

399 Citations (Scopus)

Abstract

Two markers of neuronal plasticity were used to compare the response of the human central nervous system to neuronal loss resulting from Alzheimer's disease with the response of rats to a similar neuronal loss induced by lesions. In rats that had received lesions of the entorhinal cortex, axon sprouting of commissural and associational fibers into the denervated molecular layer of the dentate gyrus was paralleled by a spread in the distribution of tritiated kainic acid-binding sites. A similar expansion of kainic acid receptor distribution was observed in hippocampal samples obtained postmortem from patients with Alzheimer's disease. An enhancement of acetylcholinesterase activity in the dentate gyrus molecular layer, indicative of septal afferent sprouting, was also observed in those patients with a minimal loss of cholinergic neurons. These results are evidence that the central nervous system is capable of a plastic response in Alzheimer's disease. Adaptive growth responses occur along with the degenerative events.

Original languageEnglish (US)
Pages (from-to)1179-1181
Number of pages3
JournalScience
Volume230
Issue number4730
DOIs
StatePublished - Jan 1 1985

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Alzheimer Disease
Dentate Gyrus
Central Nervous System
Kainic Acid Receptors
Entorhinal Cortex
Neuronal Plasticity
Cholinergic Neurons
Kainic Acid
Acetylcholinesterase
Plastics
Axons
Binding Sites
Growth

ASJC Scopus subject areas

  • General

Cite this

Geddes, J. W., Monaghan, D. T., Cotman, C. W., Lott, I. T., Kim, R. C., & Chui, H. C. (1985). Plasticity of hippocampal circuitry in Alzheimer's disease. Science, 230(4730), 1179-1181. https://doi.org/10.1126/science.4071042

Plasticity of hippocampal circuitry in Alzheimer's disease. / Geddes, James W.; Monaghan, Daniel T.; Cotman, Carl W.; Lott, Ira T.; Kim, Ronald C.; Chui, Helena Chang.

In: Science, Vol. 230, No. 4730, 01.01.1985, p. 1179-1181.

Research output: Contribution to journalArticle

Geddes, JW, Monaghan, DT, Cotman, CW, Lott, IT, Kim, RC & Chui, HC 1985, 'Plasticity of hippocampal circuitry in Alzheimer's disease', Science, vol. 230, no. 4730, pp. 1179-1181. https://doi.org/10.1126/science.4071042
Geddes JW, Monaghan DT, Cotman CW, Lott IT, Kim RC, Chui HC. Plasticity of hippocampal circuitry in Alzheimer's disease. Science. 1985 Jan 1;230(4730):1179-1181. https://doi.org/10.1126/science.4071042
Geddes, James W. ; Monaghan, Daniel T. ; Cotman, Carl W. ; Lott, Ira T. ; Kim, Ronald C. ; Chui, Helena Chang. / Plasticity of hippocampal circuitry in Alzheimer's disease. In: Science. 1985 ; Vol. 230, No. 4730. pp. 1179-1181.
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