Plasticity and maintenance of hematopoietic stem cells during development

Suman Kanji, Vincent J. Pompili, Hiranmoy Das

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Maintenance of hematopoietic stem cells (HSCs) pool depends on fine balance between self-renewal and differentiation of HSCs. HSCs normally reside within the bone marrow niche of an adult mammal. The embryonic development of HSCs is a complex process that involves the migration of developing HSCs in multiple anatomical sites. Throughout the process, developing HSCs receive internal (transcriptional program) and external (HSC niche) signals, which direct them to maintain balance between self-renewal and differentiation, also to generate a pool of HSCs. In physiological condition HSCs differentiate into all mature cell types present in the blood. However, in pathological condition they may differentiate into non-hematological cells according to the need of the body. It was shown that HSCs can transdifferentiate into cell types that do not belong to the hematopoietic system suggests a complete paradigm shift of the hierarchical hematopoietic tree. This review describes the developmental origins and regulation of HSCs focusing on developmental signals that induce the adult hematopoietic stem cell program, as these informations are very critical for manipulating conditions for expansion of HSCs in ex vivo condition. This review also states clinical application and related patents using HSC.

Original languageEnglish (US)
Pages (from-to)40-53
Number of pages14
JournalRecent Patents on Biotechnology
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Hematopoietic Stem Cells
Stem cells
Plasticity
Maintenance
Stem Cell Niche
Hematopoietic System
Adult Stem Cells
Mammals
Patents
Embryonic Development
Bone
Blood
Bone Marrow

Keywords

  • Clinical application
  • Differentiation
  • Embryonic development
  • Hematopoietic stem cells
  • Patents
  • Regulation
  • Self-renewal
  • Transdifferentiation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Plasticity and maintenance of hematopoietic stem cells during development. / Kanji, Suman; Pompili, Vincent J.; Das, Hiranmoy.

In: Recent Patents on Biotechnology, Vol. 5, No. 1, 01.01.2011, p. 40-53.

Research output: Contribution to journalReview article

Kanji, Suman ; Pompili, Vincent J. ; Das, Hiranmoy. / Plasticity and maintenance of hematopoietic stem cells during development. In: Recent Patents on Biotechnology. 2011 ; Vol. 5, No. 1. pp. 40-53.
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