Plasma proteomic profiling in HIV-1 infected methamphetamine abusers

Gwenael Pottiez, Teena Jagadish, Fang Yu, Scott Letendre, Ronald Ellis, Nichole A. Duarte, Igor Grant, Howard Eliot Gendelman, Howard S Fox, Pawel S Ciborowski

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.

Original languageEnglish (US)
Article numbere31031
JournalPloS one
Volume7
Issue number2
DOIs
StatePublished - Feb 16 2012

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Methamphetamine
Human immunodeficiency virus 1
Proteomics
proteomics
blood proteins
HIV-1
Blood Proteins
HIV
Plasmas
Oxidative stress
Coagulation
coagulation
complement
Proteins
oxidative stress
proteins
sampling
Oxidative Stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Plasma proteomic profiling in HIV-1 infected methamphetamine abusers. / Pottiez, Gwenael; Jagadish, Teena; Yu, Fang; Letendre, Scott; Ellis, Ronald; Duarte, Nichole A.; Grant, Igor; Gendelman, Howard Eliot; Fox, Howard S; Ciborowski, Pawel S.

In: PloS one, Vol. 7, No. 2, e31031, 16.02.2012.

Research output: Contribution to journalArticle

Pottiez G, Jagadish T, Yu F, Letendre S, Ellis R, Duarte NA et al. Plasma proteomic profiling in HIV-1 infected methamphetamine abusers. PloS one. 2012 Feb 16;7(2). e31031. https://doi.org/10.1371/journal.pone.0031031
Pottiez, Gwenael ; Jagadish, Teena ; Yu, Fang ; Letendre, Scott ; Ellis, Ronald ; Duarte, Nichole A. ; Grant, Igor ; Gendelman, Howard Eliot ; Fox, Howard S ; Ciborowski, Pawel S. / Plasma proteomic profiling in HIV-1 infected methamphetamine abusers. In: PloS one. 2012 ; Vol. 7, No. 2.
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